Box C/D RNAs are small, noncoding RNAs that function in RNA modification in eukaryotes and archaea. Here, we report that box C/D RNAs exist in the rare biological form of RNA circles in the hyperthermophilic archaeon Pyrococcus furiosus. Northern analysis of box C/D RNAs reveals two prominent RNA species of different electrophoretic mobilities in total P. furiosus RNA preparations. Together, th...

Recent years have witnessed many remarkable discoveries in the life sciences that have led to major paradigm shifts. An example is the emerging appreciation of the critical role of noncoding RNAs in a broad range of physiological and pathological processes. One such class of noncoding RNAs, the microRNAs (miRNAs), controls intricate networks of gene expression via post-transcriptional mechanism...

Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...

The nucleotide sequences of 4.5S RNAs associated with poly-(A)-containing RNAs of mouse and hamster cells were determined. These RNAs have 91 to 94 nucleotides, a high content of G (almost 40%) and no modified nucleoside. The 5'-termini are pppG, but the 3'-termini lack uniformity in the number of uridylate residues. These molecules contain two sets of repeating sequences, and a central purine-...

The noncoding RNAs database is a collection of currently available sequence data on RNAs, which have no protein-coding capacity and have been implicated in regulation of cellular processes. The RNAs included in the database form very heterogenous group of molecules that act on different levels of information transmission in the cell. It includes RNAs acting on the level of chromatin structure, ...

زمینه و هدف: خلق مثبت انعطاف‌پذیری شناختی از عوامل تقویت کننده خلاقیت شناخته‌ می‌شوند. مطالعه حاضر با این فرض که احتمالاً اثرگذاری بر موجب ارتقا می‌شود، مهم را در بازه سنی 8 تا 12 سال بررسی کرده است. روش پژوهش: جامعة پژوهش شامل کلیه دانش آموزان دختر ۱۲ ساله مناطق 4 ۸ شهر تهران بودند. جامعه 60 نفر دو گروه ۱۰ (76/0±80/8) (76/0±20/11) به نمونه‌گیری دسترس انتخاب شد. پس جایگذاری تصادفی افراد گروه‌های...

the tlr4 gene structure as the main receptor for lipopolysaccharide recognition of gram-negative bacteria was investigated in two strains of iranian commercial arian line and west azerbaijan native chicks and its expression was studied in some major organs. blood samples of the 120 birds were taken and total dnas extracted. then, the target gene was sequenced using four pairs of primers on four...

micrornas (mirnas) are short, endogenous non-coding rnas that function as guide molecules to regulate transcription of their target messenger rnas. several methods including low-density qpcr arrays are being increasingly used to profile the expression of these molecules in a variety of different biological conditions. reliable analysis of expression profiles demands removal of technical variati...