This review deals with recent organo-catalyzed/initiated developments of co-polymerization cyclic anhydrides and epoxides to access polyesters.

Differently substituted β-hydroxy- and β-amino dialkyl alkyl-aryl tellurides selenides have been prepared through ring-opening reactions of epoxides aziridines with selenium- or tellurium-centered nucleophiles. The antioxidant properties the cytotoxicity such compounds investigated on normal human dermal fibroblasts. Most studied exhibited a low number them proved to be non-toxic, not showing a...

Addition of carboxylic acid dianions appears to be a potential alternative to the use of aluminium enolates for nucleophilic ring opening of epoxides. These conditions require the use of a sub-stoichiometric amount of amine (10% mol) for dianion generation and the previous activation of the epoxide with LiCl. Yields are good, with high regioselectivity, but the use of styrene oxide led, unexpec...

A copper-catalyzed cross-coupling reaction of epoxides with arylboronates is described. This reaction is not limited to aromatic epoxides, because aliphatic epoxides are also suitable substrates. In addition, N-sulfonyl aziridines can be successfully converted into the products. This reaction provides convenient access to β-phenethyl alcohols, which are valuable synthetic intermediates.

Kinetic resolution of a series fluorinated styrene oxide derivatives was studied using halohydrin dehalogenase. A mutant HheC-W249P catalysed nucleophilic ring-opening with azide and cyanide ions excellent enantioselectivity (E-values up to >200), which gives access various enantiopure ?-substituted alcohols epoxides. It found that the enzyme tolerates substrates in concentrations over 50 mM. H...

The development, application, and advantages of a one-flask multicomponent dithiane linchpin coupling protocol, over the more conventional stepwise addition of dithiane anions to electrophiles leading to the rapid, efficient, and stereocontrolled assembly of highly functionalized intermediates for complex molecule synthesis, are described. Competent electrophiles include terminal epoxides, epic...