Simultaneous estimation of rilpivirine (RLVN) and dolutegravir (DTGR) in bulk tablet dosage forms via RP-HPLC-PDA with a Box–Behnken design (BBD) has been performed this study to develop fast, precise, timely cost-saving method for estimating RLVN DTGR forms. The chromatographic conditions were optimized the BBD, developed was validated according ICH guidelines. Additionally, forced degradation...