OBJECTIVE To compare the efficacy of intravenous immunoglobulin (IVIg) and exchange transfusion (EXT) on rhesus haemolytic disease of the newborn (Rh-HDN) and evaluate treatment-related side effects. METHODS Retrospective chart review of two cohorts of newborns with Rh-HDN, treated with (Group 2) or without (Group 1) IVIg. Length of phototherapy, number of EXT, IVIg infusions, intrauterine an...

In this study, we assessed the feasibility of fetal RhD genotyping by analysis of cell-free fetal DNA(cffDNA) extracted from plasma samples of Rhesus (Rh) D-negative pregnant women by using real-time polymerase chain reaction (PCR). Fetal genotyping was performed on 30 RhD-negative women between 9 and 39 weeks of gestation who were referred to us for invasive testing [amniocentesis/chorionic vi...

We report a new entity of prominent decidual vasculature overlying the internal cervical os which caused life-threatening antepartum uterine bleeding in a rhesus (Rh) D-negative patient at 32(+5) weeks' gestation. Cesarean hysterectomy was performed because of diffuse placenta increta. Early hospitalization, advanced preparation for emergency cesarean section, and timely blood transfusion, incl...

Anti-f alloantibody is produced by exposure to the f (ce) antigen on red blood cells (RBCs), which is a compound antigen of the Rhesus (Rh) blood group, expressed when both c and e antigens are present in the same haplotype (in cis). Although anti-f alloantibody was first discovered in 1953 and it has rarely been detected, the results of its detection were not reported as images in previous stu...

Rhesus (Rh) isoimmunization presenting as severe neonatal hemolytic disease is rare in RhD negative primigravidas of Chinese ethnicity. We report the case of a 32-year-old pregnant Taiwanese woman, RhD negative, who gave birth vaginally to two RhD-positive full-term fetuses 6 years apart. Antenatal follow-up was uneventful and there was no obvious fetal-maternal hemorrhage except at the perform...

Hepatitis B and HIV infection are two viral infections that represent real global public health problems. In order to improve their management, some hypotheses suggest that genetic predispositions like ABO and Rh blood groups would influence the occurrence of these diseases. The aim of the present study was to examine the association between ABO and Rhesus blood groups and the susceptibility to...

1 Nicolaides KH, Soothill PW, Clewell WH, Rodeck CH, Mibashan R, Campbell S. Fetal haemoglogin measurement in the assessment of red cell isoimmunisation. Lancet 1988;i: 1073-5. 2 Rodeck CH, Nicolaides KH, Warsof SL, Fysh WJ, Gamsu HR, Kemp JR. The management of severe rhesus isoimmunisation by fetoscopic intravascular transfusions. Amj Obstet Gynecol 1984;150:769-74. 3 Nicolaides KH, Soothill P...