GI inflammation is associated with an increase in nitric oxide production and expression of the inducible isoform of nitric oxide synthase (iNOS). Using a spontaneous model of chronic colonic inflammation in rhesus monkeys, which shares morphological and clinical features with ulcerative colitis, we assessed the therapeutic benefit of administration of iNOS inhibitors. Sixteen colitic rhesus mo...

Background and objective: Anterior thalamic nucleus deep brain stimulation (ATN-DBS) has been shown to be an effective method in seizure reduction. However, its underlying mechanisms remain unclear. This study aimed to determine the potential beneficial effects of ATN-DBS on hippocampus in epileptic rhesus monkeys. Methods: Eighteen rhesus monkeys were randomly divided into three groups: contro...

1. It has been possible to introduce yellow fever virus into the small Brazilian monkeys, Callithrix albicollis and Leontocebus ursulus, by the bites of infected mosquitoes and to carry the virus through a series of four passages in each species and back to rhesus monkeys by the bites of Stegomyia mosquitoes fed on the last marmoset of each series. 2. Five specimens of L. ursulus were used. Fou...

PURPOSE Influence of longitudinal chromatic aberration (LCA) on emmetropization during early eye development has not been studied in primates. We investigated the effects of quasi-monochromatic lighting on refractive development and eye growth in rhesus monkeys. METHODS Infant rhesus monkeys were raised under one of three lighting conditions for 51 weeks: quasi-monochromatic blue light (peak ...

Three Rhesus monkeys were maintained at 200 FSW equivalent and tested on the reversal of a previously trained visual discrimination problem. All three monkeys displayed a higher percent of errors on this reversal problem than on another reversal problem tested on the surface. These data, supplemented by changes in the monkeys' post-response stimulus observation time, are interpreted as possible...

In rhesus monkeys the Toomey "T" strain of poliomyelitis virus could not be detected in cervical or thoracic duct lymph after intranasal or intracerebral inoculation.

Acute disseminated encephalomyelitis has been produced in rhesus monkeys by injection of their own brain tissue, removed surgically and incorporated with adjuvants.

Aspiration lesions of the amygdala were found previously to produce a severe impairment in visual discrimination learning for auditory secondary reinforcement in rhesus monkeys (Gaffan and Harrison, 1987). To determine whether excitotoxic amygdala lesions would also produce this effect, we trained four naive rhesus monkeys on the same task. The monkeys were required to learn 40 new visual discr...

The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intr...

We examined the effects of early rearing experience on the development of dominance status in 53 juvenile (age 3) and then in 38 adult (ages 5-8) rhesus macaques. Based on previous research investigating the behavioral outcomes of nursery-rearing, we predicted that mother-reared (MR) monkeys would outrank peer-only reared (PR) monkeys, which would in turn outrank surrogate/peer-reared (SPR) sub...