The interaction of salicylate with the respiratory chain of liver mitochondria generates hydrogen peroxide and, most probably, other reactive oxygen species, which in turn oxidize thiol groups and glutathione. This oxidative stress, confirmed by the prevention of action by antioxidant agents, leads to the induction of the mitochondrial permeability transition in the presence of Ca2+. This pheno...

We design an infrastructure experiment in Mexico to evaluate the impact of firsttime asphalting of inhabited residential streets on property values and household outcomes. We find substantial impacts on housing values (+16%) and land values (+54%). At the household level, street paving increased the use of collateral-based credit, and had strong effects on vehicle ownership (+43%), durable good...

e has in his make-up two essential elements— common sense and the will to work ... in collecting [facts] he is diligent, patient, careful, thorough and unbiased ... he avoids needless or obfuscating high mathematics and formulae ... he does not twist the facts... He remains broad-minded and open-minded ... He is humble in his ignorance but bold in his search for truth " (1). So wrote legendary ...

Références [1]Vachharajani A.J., Shah J.K., Paes B.A. Late onset left diaphragmatic hernia after group B streptococcal sepsis. J Pediatr Surg 2002; 37: 932-3. [2]-Garcia-Munoz F, Santana C, Reyes D et al. Early sepsis, obstructive jaundice and right-side diaphragmatic hernia in the new born. Acta Paediatr 2001; 90:96-8. [3]-Harris MC, Moskowitz WB, EngleWD et al. Group B streptococcal septicaem...

The association between inherited metabolic disorders and the sudden infant death syndrome (SIDS) received considerable attention in the mid to late 1980s. The earlier reports suggested that as many as 5-10% of all cases of SIDS in the UK could be due to metabolic disorders.' 2 More recent publications, however, suggest a more conservative estimate that such disorders probably account for fewer...

The consumption of medicines among a population-based cohort of 4,746 children born in 1982 in Pelotas, Brazil, was studied when the children were aged 3-4.5 years. Fifty six percent of the mothers reported that their children had taken one or more medicines during a two-week period; 29.5% of the products were fixed combinations of three or more components, (which was taken as an indicator of p...

/ 12 Fig. 1.Assay ofserum creatine kinase A denotesthe IncreasedCX activity (predominantly MM isoenzyme)of serumfrom a patient with myo-cardlal infarction; B, elevated CX activity (predom-inantlyMM isoenzyme)of serumfrom a patientwith Rey&s syn&ome, following a greatly extended Incubation period(a 10-fold Increase in the concen-trationofs*ifrsy&)l activating agentsdoesnotaffect the dizatlon of ...

In the 1980s, genetic and fossil evidence began to call attention to Africa’s preeminence in the origins of modern human populations (1), but this evidence could be interpreted in two fundamentally different ways (2). Was Africa’s role greater than other continents because it always harbored a larger human population (size) or because modern humans arose in Africa first and subsequently expande...

MARTÍNEZ-GONZÁLEZ, B.; THERIOT-GIRÓN, M. C.; LÓPEZ-SERNA, N; MORALES-AVALOS, R.; QUIROGA-GARZA, A.; REYES-HERNÁNDEZ, C. G.; VILLANUEVA-OLIVO, A.; LEYVA-VILLEGAS, J. I.; SOTO-DOMÍNGUEZ, A.; DE LA FUENTE-VILLARREAL, D.; ELIZONDO-OMAÑA, R. E. & GUZMÁN-LÓPEZ, S. Morphological analysis of major segments of coronary artery occlusion. Importance in myocardial revascularization surgery. Int. J. Morphol...

DEDICATION To my friends and family, without whom none of this would have been possible. and Jeremy – thank you. v ACKNOWLEDGMENTS I would first like to my advisors, Professor Alex Briseno and Professor Jim Watkins. Their guidance and support throughout my graduate studies has been phenomenal. Alex has been a treasure trove of information with his encyclopedic knowledge of the literature. Moreo...