TRAINS which approach wild type in appearance or behavior can arise from s mutant strains as a result of either reversion (mutation at the original mutant locus) or suppression (mutation at some other genetic locus). In microorganisms both reversions ( HOGNESS and MITCHELL 1954) and some suppressor mutations (YANOFSKY 1952; PARKS and DOUGLAS 1957) are known to act by restoring the specific enzy...

ONHERITABLE repair of a mutant phenotype resulting from errors in translation was first described by BENZER and CHAMPE (1961) for rZZ mutants of phage T4. These mutants are ordinarily unable to grow on Escherichia coli strain KB, but can grow on strain B. Treatment of infected KB cells with 5-fluorouracil (5FU) resulted in a large increase in phage yield with certain rZZ mutants, yet the progen...

This paper shows pricing and hedging efficiency of a three factor stochastic mean reversion Gaussian model of commodity prices using oil and copper futures and forward contracts. The model is estimated using NYMEX WTI (light sweet crude oil) and LME Copper futures prices and is shown to fit the data well. Furthermore, it shows how to hedge based on a three-factor model and confirms that using t...

Farnesyltransferase inhibitors (FTIs) are a novel class of anticancer drugs that can reverse Ras transformation. One of the intriguing aspects of FTI biology is that continuous drug exposure is not necessary to maintain phenotypic reversion. For example, after a single exposure to FTIs, Ha-Ras-transformed fibroblasts revert to a flat and anchorage-dependent phenotype that persists for many days...

Reversion phenomena in the FCC Ising system was investigated using the kinetic Ising model. The results were compared with the experimental results obtained for the metastable G.P. zones in Al-Zn binary alloys. The present simulations have made it clear that the kinetic Ising model can qualitatively well reproduce the structure change during reversion in the Al-Zn metastable system. Comparison ...

Farnesyltransferase inhibitors (FTIs) are a novel class of anticancer drugs that can reverse Ras transformation. One of the intriguing aspects of FTI biology is that continuous drug exposure is not necessary to maintain phenotypic reversion. For example, after a single exposure to FTIs, Ha-Ras-transformed fibroblasts revert to a flat and anchoragedependent phenotype that persists for many days ...

We consider two Gaussian measures. In the "initial" measure the state variable is Gaussian, with zero drift, and time-varying volatility. In the "target measure" the state variable follows an Ornstein-Uhlenbeck process, with a free set of parameters, namely the time-varying speed of mean-reversion. We look for the speed of mean reversion that minimizes the variance of the Radon-Nikodym derivati...

Lignin peroxidase compound III (LiPIII) was prepared via three procedures: (a) ferrous LiP + O2 (LiPIIIa), (b) ferric LiP + 0; (LiPIIIb), and (c) LiP compound II + excess HzOz followed by treatment with catalase (LiPIIIc). LiPIIIa, h, and c each have a Soret maximum at -414 nm and visible hands at 543 and 578 nm. LiPIIIa, b, and c each slowly reverted to native ferric Lip, releasing stoichiomet...

.The book under review is an eminently readable digression into subjects medical, psychic, metaphysical, poetical and other themes equally interesting. To define the scope of the work in the author's words " Biological reversion is a clinical method designed to define and rectify the consequences of chronic toxaemia." A detailed anatomical analysis is made of the skin, the subcutaneous tissues,...