PURPOSE ZBED4, a protein in cones and Müller cells of human retina, may play important functions as a transcriptional activator of genes expressed in those cells or as a co-activator/repressor of their nuclear hormone receptors. To begin investigating these potential roles of ZBED4, we studied the developmental expression and localization of both the Zbed4 mRNA and protein of mouse retina. ME...

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization glucose levels delays its progression. In hyperglycemia, hexokinase saturated and excess metabolized to sorbitol by aldose reductase via the polyol pathway. Therapies reduce retinal accumulation prevention DR have been elusive because low dehy...

Retinal detachment (RD), its rupture, concussion, hemorrhage require urgent ophthalmic surgical intervention without fail. Restoring the anatomical integrity of detached retina, speed intervention, choice access and method surgery, quality instrument are directly causally related to visual acuity, number severity postoperative complications. The best complex ophthalmosurgical solutions relieve ...

The incorporation of transplanted cells into the host retina is one of the prerequisites for successful cell replacement therapy to treat retinal degeneration. To test the hypothesis that injury promotes cell incorporation, stem cells/progenitors were isolated from the retina, ciliary epithelium or limbal epithelium and transplanted into the eyes of rats with retinal injury. Different stem cell...

Microglial cell precursors located in the area of the base of the pecten and the optic nerve head (BP/ONH) start to enter the retina of quail embryos at the 7th day of incubation (E7), subsequently colonizing the entire retina by central-to-peripheral tangential migration, as previously shown by our group. The present study demonstrates a precise chronological coincidence of the onset of microg...