Induction of granulocytic differentiation in HL-60 myeloid leukemia cells by retinoids is followed by their death via apoptosis. Retinoids are known to mediate their biological effects through at least two distinct types of nuclear receptors, the retinoic acid receptors and retinoid X receptors. We undertook to characterize the potential role of these receptors in inducing differentiation and a...

The greater incidence of diseases of the ovary during the childbearing period renders their occurrence as complications of pregnancy and labour far from surprising.' Ovarian disease does not afford an effective barrier to conception. Spiegelberg, for example, reports that on two occasions he examined soon after labour cancerous growths of both ovaries in which not a trace of healthy tissue rema...

Let K be a totally real number field and consider Fermat-type equation A p + B b q = C c r $Aa^p+Bb^q=Cc^r$ over K. We call the triple of exponents ( , ) $(p,q,r)$ signature equation. prove various results concerning solutions to Fermat with 2 $(p,p,2)$ 3 $(p,p,3)$ using method involving modularity, level lowering image inertia comparison. These generalize extend recent work I?ik, Kara Özman. F...

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a...

Mutations in the genes ovo or otu can cause abnormal proliferation of XX germ cells, which leads to so-called ovarian tumors, or they can lead to the elimination of XX germ cells, such that adult females possess empty ovaries. Males carrying ovo or otu mutations are unaffected. To find out when this sexual dimorphism affects germ cells, we analyzed the requirement of embryos and larvae for zygo...