Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...

BACKGROUND Xenobiotic chemicals with estrogenic activity (EA), such as bisphenol A (BPA), have been reported to have potential adverse health effects in mammals, including humans, especially in fetal and infant stages. Concerns about safety have caused many manufacturers to use alternatives to polycarbonate (PC) resins to make hard and clear, reusable, plastic products that do not leach BPA. Ho...

background: this paper describes the common hazards in the metal industry – chemicals and noise. the aim of the study was to get an overview of risk levels of mentioned occupational hazards and examine the implementation of adequate safety measures. methods: measurements of noise and chemicals were performed, self-reported exposure and usage of personal protective equipment from workers were us...

Rice blast, caused by Magnaporthe oryzae, poses a significant threat to rice production. blast susceptibility has been observed in Japanese varieties with excellent eating quality. Enhancing resistance is essential ensure minimal use of agricultural chemicals. Two types are observed: True resistance, which type qualitative expressed major gene, and field quantitative multiple micro-acting genes...

The article deals with consumer behaviour when purchasing green products. It develops theoretical knowledge in the field of antecedents to purchase intention a focus on currently neglected chemicals (detergents, cleaning agents and cosmetic products). Based previous studies, for are identified significance their influence is subsequently verified by empirical research. Confirmatory analysis bas...