Long-term soft denture lining (LTSDL) materials are used to alleviate the trauma associated with wearing complete dentures. Despite their established clinical efficacy, the use of LTSDLs has been limited due to the unfavorable effects of the oral environment on some of their mechanical and performance characteristics. The unresolved issue of LTSDL colonization by Candida albicans is particularl...

The epithelium lining the mouse larynx occupied the transitional zone between the keratinized stratified squamous epithelium lining the oral cavity and the ciliated columnar one continuing to the trachea. The epithelium showed gradations ranging from stratified squamous through stratified cuboidal to ciliated stratified low-columnar type. It is suggested that the epithelium is identical with th...

In this issue of Neuron, Roelfsema and Spekreijse report that macaque V1 neuron responses are correlated with target choice in a task requiring monkeys to attentively trace a line to plan a saccade. These results provide evidence that V1 is actively involved in the interpretation of visual stimuli.

Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced g...

The aim of this study was to determine aztreonam (ATM) membrane permeability using Calu-3 cells and its plasma and pulmonary epithelial lining fluid (ELF) pharmacokinetics in rats after intratracheal nebulization and intravenous administration (15 mg · kg(-1)). ATM exhibits low Calu-3 permeability (0.07 ± 0.02 × 10(-6) cm · s(-1)), and a high area under the ELF/unbound plasma concentration time...

Limitations on water resources and the high costs of new hydraulic structure construction intensify the need for an optimum operation of Iranian reservoir systems. For appropriate water distribution and management in a 9-reservoir system on the Kalamarz river, Mianeh basin optimizing mathematical models are applied. Considering the stochastic nature of river discharges and the constant amount o...