Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Th...

An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the ...

Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxicity in the presence of a m...

Studies on the Mechanism of the Hypertensive Effect of Prostaglandin F . D. W. DUCHARME, J. R. WEEKS AND R. G. MONTGOMERY 1 Venoconstrictive Action of Bradykinin. RICHARD P. BOBBIN AND PAUL S. GUTH... 11 Antiarrhythmic Activity of Some Isoquinoline Derivatives Determined by a Rapid Screening Procedure in the Mouse. JAMES W. LAWSON 22 The Effects of Reserpine on Vasopressin-Cholesterol-Induced A...

Steric Aspects of Adrenergic Drugs. I. Comparative Effects of DL Isomers and Desoxy Derivatives. P. N. PATIL, J. B. LAPIDUS AND A. TYE 1 Steric Aspects of Adrenergic Drugs. II. Effects of DL Isomers and Desoxy Derivatives on the Reserpine-Pretreated Vas Deferens. P. N. PATIL, J. B. LAPInus, D. CAMPBELL AND A. TYE 13 Steric Aspects of Adrenergic Drugs. III. Sensitization by Cocaine to Isomers of...

The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg). Fortynine ambulant patients (30 men, 19 women) were treated throughout the study with hydrochlorothiazide, 50 mg/day. In this double blind crossover study each drug was added in graded increments until a predetermined ther...