Improvement in the usage of an effective therapeutic agent is highly desirable especially when the method of administration is simplified, the total dosage reduced, the toxicity of the drug diminished and the cost of medical care lessened. The replacement of parenteral injections of the mercurial diuretics by an oral preparation in ambulatory patients in chronic congestive heart failure represe...

This paper presents a method to find the optimal production, repair/replacement and preventive maintenance policies for a degraded manufacturing system. The system is subject to random machine failures and repairs. The status of the system is deemed to degrade with repair activities. When a failure occurs, the machine is either repaired or replaced, and a replacement action renews the machine, ...

This paper presents a novel method for stance and swing phase detection employing Learning Vector Quantization (LVQ), using knee angle information only. The results show detection accuracy of 95.9% in stance phase and 83.9% in swing phase. The research concludes an efficient replacement of footswitch for phase detection. The work can directly lead to low cost speed adaptive transtibial prosthes...

For repairable items sold with free replacement warranty, the actions available to the manufacturer to rectify failures under warranty are to (1) repair the failed item or (2) replace it with a new one. A proper repair-replace strategy can reduce the expected cost of servicing the warranty. In this paper, we study repair-replace strategies for items sold with a two-dimensional free replacement ...

OBJECTIVE To compare the cost effectiveness of the three most commonly chosen types of prosthesis for total hip replacement. DESIGN Lifetime cost effectiveness model with parameters estimated from individual patient data obtained from three large national databases. SETTING English National Health Service. PARTICIPANTS Adults aged 55 to 84 undergoing primary total hip replacement for oste...

OBJECTIVE The objective of this study is to evaluate the economic benefits of immunoglobulin replacement therapy achieved subcutaneously (subcutaneous immunoglobulin, SCIG) by the rapid push method compared to intravenous infusion therapy (intravenous immunoglobulin, IVIG) in primary immune deficiency (PID) patients from the healthcare system perspective in the context of the adult SCIG home in...

Cache replacement strategy is the core for a distributed high-speed caching system, and effects the cache hit rate and utilization of a limited cache space directly. Many reports show that there are temporal and spatial local changes in access patterns of geospatial data, and there are popular hot spots which change over time. Therefore, the key issue for cache replacement strategy for geospati...

today power consumption is considered to be one of the important issues. therefore, its reduction plays a considerable role in developing systems. previous studies have shown that approximately 50% of total power consumption is used in cache memories. there is a direct relationship between power consumption and replacement quantity made in cache. the less the number of replacements is, the less...

Porous silicon was successfully prepared using metal-assisted chemical etching method. The Effect of HF/H2O2 concentration in etching solution as an affecting parameter on the prepared porosity type and size was investigated. Field emission electron microscopy (FE-SEM) confirmed that all etched samples had porous structure and the sample which was immersed into HF/H2O2 withmolar ratio of 7/3.53...

A green method for the synthesis of high-performance diketopyrrolopyrrole pigments using diethyl succinate in the presence of mixture of ionic liquids is reported. Although, alkaline condition is needed in the succinate ester route for synthesis of the pigments, in the present study, the replacement possibility of conventional organic base by mixture of BMIMOH and BMIMBF4 ionic liquids was inve...