BACKGROUND The primary analysis in a longitudinal randomized controlled trial is sometimes a comparison of arms at a single time point. While a two-sample t-test is often used, missing data are common in longitudinal studies and decreases power by reducing sample size. Mixed models for repeated measures (MMRM) can test treatment effects at specific time points, have been shown to give unbiased ...

Thrombophilia is a group of inherited and acquired coagulation disorders often associated with an increased risk of thrombosis. Over the last decade, inherited thrombophilia is often referred as a possible cause of recurrent miscarriages and in vitro fertilisation (IVF) failure. However, many studies in this area still give conflicting results, so the goal of our study was to determine the effe...

background: Several studies have examined the relationship between direct antisperm antibody (ASA) levels in semen and pregnancy rate after advanced assisted reproductive technologies (ARTs) but the results have been inconsistent. The aim of our study was to further evaluate the relationship between ASA and pregnancy after IVF or ICSI by systematic review and meta-analysis. methods: We conducte...

Although somatic cell nuclear transfer (SCNT) cloning is more efficient in cattle than in any other species tested so far, there is a high rate of pregnancy failure that has been linked to structural and functional abnormalities of the placenta. We tested the hypothesis that these changes may originate from disturbed embryo-maternal interactions in the peri-implantation period. Therefore, we ev...

Natural cycles were abandoned in in-vitro fertilization (IVF) embryo transfer, due to premature luteinizing hormone (LH) surges--and subsequent high cancellation rates. In this study, we investigated the administration of a new gonadotrophin-releasing hormone antagonist (Cetrorelix) in the late follicular phase of natural cycles in patients undergoing IVF and intracytoplasmic sperm injection (I...

The objective of this study was to assess the impact on pregnancy outcome of excising hydrosalpinx(ges) in patients with repeated in-vitro fertilization (IVF) failures. A group of 15 patients who had previously undergone failed IVF attempts and had unilateral or bilateral hydrosalpinx was subjected to an operative laparoscopy with excision of the affected tube(s). Of these, 10 patients underwen...

PURPOSE To use binocular integrated visual field (IVF) measures to predict which patients will lose visual function to a level below the legal standard for driving. METHODS Data from patients attending a glaucoma clinic were collected longitudinally. The time from baseline until failure to meet the criteria of the driver's license test was modeled with Cox regression. Visual field status at b...

Background: Protein C deficiency is a rare disease; it could be primary or secondary. Female patients with protein may develop pregnancy-associated thrombosis. The clear association between the and fertility in-vitro fertilization (IVF) results has not been known yet. In our study, we aimed to determine prevalence of in Syrian infertile women assess impact on abortion, recurrent IVF Failure, re...

Available for download in Word Document format Summary pFSH therapy for the male suffering from severe OTA or non-obstructive “maturation arrest” azoospermia is beneficial, improving fertilization and implantation rates. It is possible that improved embryo quality, due to improved paternal factor, contributes to these results. Introduction Our group presented recently that pFSH (Metrodin) admin...

Abstract Implantation depends on bi-directional communication between the blastocyst and endometrium. Encoded in this is information maternal embryonic fitness, which turn can lead to activation of species-specific reproductive suppression mechanisms. For example, blastocysts over 130 mammals, although not humans, respond presence or absence specific endocrine endometrial cues by entering exiti...