RAD3 functions in DNA repair and transcription in Saccharomyces cerevisiae and particular rad3 alleles confer a mutator phenotype, possibly as a consequence of defective mismatch correction. We assessed the potential involvement of the Rad3 protein in mismatch correction by comparing heteroduplex repair in isogenic rad3-1 and wild-type strains. The rad3-1 allele increased the spontaneous mutati...

The discovery of nucleotide excision repair in 1964 showed that DNA could be repaired by a mechanism that removed the damaged section of a strand and replaced it accurately by using the remaining intact strand as the template. This result showed that DNA could be actively metabolized in a process that had no precedent. In 1968, experiments describing postreplication repair, a process dependent ...

Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations, such as in cancer. Base excision repair and nucleotide excision repair are the two DNA repair pathways believed to orchestrate the removal of oxi...

Ballast as a part of the railway system plays an important role in the operation of the railways and also has a great impact on repair and maintenance activities. Hence most of the repair and maintenance activities in traditional railway systems are due to the defections in the ballast layer and therefore most of the maintenance budget is spent on repairing these defects. These repair and maint...

Background: Nickel is a carcinogenic, heavy metal released through industrial activities and via natural resources. It is able to cause DNA damages by reducing the efficiency of DNA repair mechanisms. However, the exact time point at which it is able to interfere with these mechanisms is not yet clearly understood. Methods: To find the most nickel-vulnerable time of repair mechanisms, human de...

The demand of self-testing proportionally increases with memory size in System on Chip (SoC). SoC architecture normally occupies the majority of its area by memories. Due to increase in density of embedded memories, there is a need of self-testing mechanism in SoC design. Therefore, this research study focuses on this problem and introduces a smooth solution for self-testing.  In the proposed m...

This investigation deals with the transient analysis of the machine repair system consisting of M-operating units operating under the care of single repairman. To improve the system reliability/availability, Y warm standby and S cold standby units are provided to replace the failed units. In case when all spares are being used, the failure of units occurs in degraded fashion. In such situation ...

The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development. The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how deterioration of this process is associated w...

Abstract Repair and maintenance operations of wind turbines constitute a significant part costs energy. In this paper, technologies structural repair damaged turbine blades are reviewed. Costs repair, technological contribution to the discussed. Technologies compared, including hand layup lamination, vacuum with infusion, ultraviolet curing high temperature thermal systems. Computational models...