Title: Effectiveness of endoscopic endonasal transsphenoidal surgery using a neuronavigation: Clinical results of 178 pituitary adenomas Background: The present study assesses endoscopic endonasal transsphenoidal surgery using neuronavigation for pituitary adenoma. Methods and findings: Data were analyzed from 178 consecutive patients with pituitary adenomas who underwent endoscopic endonasal t...

Background and Objectives. Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. Methods. The study group comprised 38 patients with UC in clinical remission on total colonoscopy who were followed up for at least 5 years. Clinical remission was d...

To describe the clinical and biologic features of pediatric acute megakaryoblastic leukemia (AMKL) and to identify prognostic factors, experience at St Jude Children's Research Hospital was reviewed. Of 281 patients with acute myeloid leukemia treated over a 14-year period, 41 (14.6%) had a diagnosis of AMKL. Six patients had Down syndrome and AMKL, 6 had secondary AMKL, and 29 had de novo AMKL...

BACKGROUND Optimal chemotherapy with minimal toxicity is the main determinant of complete remission in patients with newly diagnosed hematological malignancies. Acute organ dysfunctions may impair the patient's ability to receive optimal chemotherapy. DESIGN AND METHODS To compare 6-month complete remission rates in patients with and without acute kidney injury (AKI), we collected prospective...

BACKGROUND Hidradenitis suppurativa (HS) causes considerable morbidity. The long-term prognosis is of obvious interest to both patients and physicians. We conducted this study to determine the prognosis and risk factors in patients diagnosed with HS. OBJECTIVES To describe the long-term prognosis and the clinical course of HS and its association to known risk factors. METHODS A postal follo...

BACKGROUND and aims: In this prospective study, we determined the long term clinical course of patients with achalasia who were treated by pneumatic dilation using the Browne-McHardy dilator, and determined whether previously described predictors of outcome remain significant after prolonged follow up. METHODS Between 1981 and 1991, 54 consecutive patients were treated by pneumatic dilation a...

BACKGROUND AND AIM The aim of the present study was to endoscopically evaluate ileal mucosal healing during maintenance therapy with infliximab in order to investigate the clinical significance of endoscopic examination of ileal lesions in Crohn's disease patients. METHODS This study retrospectively analyzed 54 patients who mainly had active ulcers of the ileum on endoscopy at baseline who we...

OBJECTIVE Recent studies have questioned the reversibility of complications of Cushing's syndrome (CS) after successful surgical treatment. The aim of this study was to assess the outcome of patients with CS who achieved disease remission compared with those patients with persistent hypercortisolism and matched controls. DESIGN A retrospective study of 75 patients with CS followed at an acade...

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

Major progress in the treatment of children with acute myelogenous leukemia has occurred in the past decade. Advances in chemotherapy and supportive care have been associated with an increase in the complete remission (CR) rate, and more important, an increase in the duration of first remission [1, 5]. In addition, bone marrow transplantation in first remission may provide a new approach for a ...