Abstract Oncolytic adenoviruses (OAs)‐based virotherapy can regulate the tumor microenvironment, providing a rational strategy for combination treatment with other therapy techniques, such as transcatheter arterial embolization (TAE). Here, novel, validated viroembolization (TAVE) strategy—a calcium alginate hydrogel microsphere OA encapsulated (OA@Alg beads) to achieve of TAE oncolytic enhance...

The microsphere model and the continuous withdrawal of arterial blood have been commonly used in clinical studies when measuring regional cerebral blood flow (rCBF) by N-isopropyl-p[123I]iodoamphetamine (IMP) SPECT. The method is considered to underestimate rCBF because of the washout of the tracer from brain tissue with increasing time after injection; however, the extent of this underestimati...

Hexagonally ordered arrays of polystyrene (PS) microspheres were prepared by a modified air-water self-assembly method. A detailed analysis of the air-water interface self-assembly process was conducted. Several parameters affect the quality of the monolayer colloidal crystals, i.e., the colloidal microsphere concentration on the latex, the surfactant concentration, the polystyrene microsphere ...

Alginate microspheres containing furosemide were prepared by the ionotropic external gelation technique using Ca2+, Al3+ and Ba2+ ions. The incorporation efficiency of the prepared microspheres ranged between 65% and 93%. The effect of sodium alginate concentration, cross-linking ions and drying conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristi...

PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...

The objective of the present study was to minimise the unwanted side effects of lithium carbonate (LC) drug by kinetic control of drug release, LC was entrapped into gastro resistant, biodegradable carnauba wax microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing a wetting agent. Solid, discrete, reproducible free flowing microspheres were prepare...

Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercritical carbon dioxide (CO₂) for attaching dexamethasone-loaded PLGA (polylactic...