BACKGROUND Little information is available about the incidence of complications from vacuum aspiration for first-trimester abortion after cervical preparation with prostaglandin analogues. We compared incidence of complications from vacuum aspiration in women who had had cervical preparation with misoprostol and those who had not. METHODS We did a randomised parallel-group trial at 14 centres...

labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. in other wor...

OBJECTIVES To analyze and determine the safety and effectiveness of induced fetal demise as an adjunctive method in outpatient abortion for patients with advanced pregnancies and to evaluate the independent effect of intrauterine misoprostol administered after amniotomy in late abortion. METHODS During a 9-year period, 1677 abortions were performed for patients whose pregnancies ranged from 1...

background: in developing countries it is important to the exploration of available and safe regimens for medical abortion. the present study was designed to assess the effect of letrozole compared to placebo pretreatment followed by sublingual misoprostol for therapeutic abortion in eligible women with gestational age less than 17 weeks. materials and methods: in this randomized control trail,...

Prostaglandins have revolutionalized obstetric practice. In particular, the advent of misoprostol has precipitated an enormous amount of innovative research as well as controversy. At present, misoprostol is being simultaneously investigated for its role in the management of postpartum hemorrhage (PPH), induction of labor, cervical ripening and termination of pregnancy. Initially, this drug was...

Background The current study was designed to compare the effectiveness and side effects of oral, vaginal, and sublingual misoprostol in termination of second-trimester pregnancy. Materials and Methods: In this clinical trial (2014 to 2015), 85 pregnant women in the second trimester of pregnancy were included in Imam Reza hospital, Kermanshah, Iran. They were randomly divided into three groups a...

Labor is a physiological event involving a sequential, integrated set of changes within the myometrium, deciduas, and uterine cervix that occur gradually over a period of days to weeks. Biochemical connective tissue changes in the uterine cervix appear to precede uterine contractions and cervical dilation, and all of these events usually occur before rupture of the fetal membranes. In other wor...