The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highly expressed in metastatic breast cancer-derived cell lines but not in the nonmetastatic estrogendependent MCF-7 cells. Furthermore, LOR-1 expression in periductal tumor cells of breast carcinomas is signific...