Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age-related macular degeneration. Histologically, drusen are believed to be dome-shaped or more confluent lipid accumulations between the retinal pigment epithelium and the choriocapillaries. Recent advances in mouse funduscopy have revealed the presence of drusen-like structures in chemokine knockout animals...

Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD). The cause for the accumulation and retention of molecules in the sub-RPE space, however, remains an enigma. Here, we present fluorescence microscopy and X-ray diffraction evidence f...

BACKGROUND Tumor deposits are one of the important influencing factors among the different editions of Tumor, Node, Metastasis classification. Incidence and prognosis of tumor deposits in stage I, II, and III colorectal cancer patients has been explored. The aim of this study was to determine the prognostic value of tumor deposits in stage IV colorectal cancer patients who underwent simultaneou...

impressive Quaternary lacustrine deposits are present as terrace remnants throughout the Karakoram Mountains, northern Pakistan. They are mainly the result of damming of drainage systems during glacial advances or by catastrophic mass movement deposits. The longevity of most lakes is relatively short, in the order of years to tens of yeaa, but sedimentation rates are extremely high as a consequ...

The spatial patterns of the diffuse, primitive, and classic β -amyloid (Aβ) deposits were compared in cortical regions in early-onset familial Alzheimer's disease (EO-FAD) linked to mutations of the amyloid precursor protein APP) or presenilin 1 (PSEN1) genes, late-onset familial AD (LO-FAD), and sporadic AD (SAD). The objective was to determine whether genetic factors influenced the spatial pa...

The current study examines the relationship between liquidity risk management and performance of commercial banks in Western Balkans 2015 to 2020. This is examined by using secondary data from financial statements. Financial measured return on assets, equity net interest margin. Liquidity represented quick ratio, loan-to-deposits loan-to-assets cash investment-to-deposit capital adequacy covera...

The temporal-spatial coincidence of saline deposits with rifting and alkaline magmatism has now become a commonly accepted fact. The congruency of these three phenomena implies logically, their trilateral genetic interrelation. The conventional concept for the formation of saline deposits, i.e an "evaporation process" can not be properly applied to giant saline deposits. The proposed "Volc...

Silicic tuffs infilling an ancient submarine caldera, at Mineral King in California, show microscopic fabrics indicative of welding of glass shards and pumice at temperatures >500 degrees C. The occurrence indicates that subaqueous explosive eruption and emplacement of pyroclastic materials can occur without substantial admixture of the ambient water, which would cause chilling. Intracaldera pr...

This study reports the prevalence of immune deposits associated with the proximal and distal tubules in a series of routine renal biopsies received in our department during a single calendar year. From 87 cases, 65 (74%) were found to have glomerular immune deposits by immunofluorescence. Tubular immune deposits were found in 12 cases (18%), 3 of which had no glomerular deposits. By transmissio...