OBJECTIVE Transfusion-related acute lung injury is the leading cause of transfusion-related morbidity and mortality. Clinical data on the pathogenesis of transfusion-related acute lung injury are sparse. The objective of the present study was to determine inflammation and coagulation pathways involved in the onset of transfusion-related acute lung injury. DESIGN Nested case-control study. S...

BACKGROUND Hemolytic transfusion reactions and transfusion-related acute lung injury (TRALI) are life-threatening complications associated with the transfusion of blood products. Hemorrhage is one of the most common surgical complications and the risk of bleeding is particularly acute in patients with hematologic deficiencies. Management of surgical bleeding can be divided into two phases. The ...

With the success of reducing the risk of transfusion-transmitted infectious diseases, noninfectious serious hazards of transfusion have come to the forefront with respect to transfusion safety. Transfusion-related acute lung injury has emerged as a dominant noninfectious serious hazard of transfusion. Improved understanding of its pathophysiology is needed to improve clinical strategies to deal...

A 49 year-old man with a history of alcohol-induced cirrhosis presented for orthotopic liver transplantation. His medical history is remarkable for mild hypertension treated with metoprolol and aldactone; recent admissions for ascitic fluid drainage, spontaneous bacterial peritonitis and transient episodes of hepatic encephalopathy; and a prior history of an open cholecystectomy. His admission ...

acute respiratory distress syndrome (ards) is a complex disorder of heterogeneous etiologies characterized by a consistent, recognizable pattern of lung injury and a potentially devastating form of acute inflammatory lung injury with a high short-term mortality rate and significant long-term consequences among survivors. recently, the new definition of ards has been published, and this definiti...

Transfusion-related acute lung injury is a life-threatening complication of hemotherapy associated with the transfusion of plasma-containing blood products. It is characterized by acute respiratory distress, pulmonary edema and hypoxemia. Although its frequency is unknown, Food and Drug Administration data suggest that it is the third most common cause of transfusion-associated deaths, represen...

This chapter reviews a variety of acute, nonhemolytic, and noninfectious transfusion reactions, the most common of which are febrile, nonhemolytic transfusion reactions (FNHTRs) and allergic reactions. Other acute, nonhemolytic reactions are reported less frequently and include transfusion-related acute lung injury (TRALI) and anaphylactic or anaphylactoid reactions. Additional acute adverse ef...

INTRODUCTION Transfusion-related acute lung injury is emerging as a common cause of transfusion-related adverse events. However, awareness about this entity in the medical fraternity is low and it, consequently, remains a very under-reported and often an under-diagnosed complication of transfusion therapy. CASE PRESENTATION We report a case of a 46-year old woman who developed acute respirato...