نتایج جستجو برای: regulatory t cells tregs

تعداد نتایج: 2028005  

2017
Nanhai He Weiwei Fan Brian Henriquez Ruth T. Yu Annette R. Atkins Christopher Liddle Ye Zheng Michael Downes Ronald M. Evans

The metabolic programs of functionally distinct T cell subsets are tailored to their immunologic activities. While quiescent T cells use oxidative phosphorylation (OXPHOS) for energy production, and effector T cells (Teffs) rely on glycolysis for proliferation, the distinct metabolic features of regulatory T cells (Tregs) are less well established. Here we show that the metabolic sensor LKB1 is...

Journal: :Journal of immunology 2014
Emeka B Okeke Ifeoma Okwor Jude E Uzonna

Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance, and defects in Treg function have been linked to several autoimmune diseases. We previously reported that depletion of Tregs resulted in mortality to an otherwise nonlethal dose of LPS or Escherichia coli challenge. In this study, we investigated the mechanism by which Treg depletion leads to enhanced susceptibili...

Journal: :PLoS ONE 2008
Peter C. J. Janson Malin E. Winerdal Per Marits Magnus Thörn Rolf Ohlsson Ola Winqvist

BACKGROUND Naturally occurring thymus derived regulatory T cells (Tregs) are central in the maintenance of self-tolerance. The transcription factor FOXP3 is crucial for the suppressive activity of Tregs and is considered the most specific marker for this population. However, human non regulatory T cells upregulate FOXP3 transiently upon activation which calls for other means to identify the Tre...

2011
Jing Hua Shuwen Liang Xiong Ma Tonya J. Webb James P. Potter Zhiping Li

BACKGROUND/AIMS Regulatory T cells (Tregs) and natural killer T (NKT) cells are two distinct lymphocyte subsets that independently regulate hepatic adaptive and innate immunity, respectively. In the current study, we examine the interaction between Tregs and NKT cells to understand the mechanisms of cross immune regulation by these cells. METHODS The frequency and function of Tregs were evalu...

Journal: :Journal of immunology 2010
Tokunori Ikeda Shinya Hirata Satoshi Fukushima Yusuke Matsunaga Takaaki Ito Makoto Uchino Yasuharu Nishimura Satoru Senju

TRAIL is known to play a pivotal role in the inhibition of autoimmune disease. We previously demonstrated that administration of dendritic cells engineered to express TRAIL and myelin-oligodendrocyte glycoprotein reduced the severity of experimental autoimmune encephalomyelitis and suggested that CD4(+)CD25(+) regulatory T cells (Tregs) were involved in mediating this preventive effect. In the ...

2017
Johannes Fessler Andrea Raicht Rusmir Husic Anja Ficjan Christine Schwarz Christina Duftner Wolfgang Schwinger Winfried B. Graninger Martin H. Stradner Christian Dejaco

OBJECTIVE Premature senescence of lymphocytes is a hallmark of inflammatory rheumatic diseases such as rheumatoid arthritis (RA). Early T-cell aging affects conventional T-cells but is presumably not limited to this cell population; rather it might also occur in the regulatory T-cells (Tregs) compartment. In RA, Tregs fail to halt aberrant immune reactions and disease progression. Whether this ...

2011
Zhi-Jian Ye Qiong Zhou Jian-Chu Zhang Xiao Li Cong Wu Shou-Ming Qin Jian-Bao Xin Huan-Zhong Shi

BACKGROUND Both regulatory T cells (Tregs) and T helper IL-17-producing cells (Th17 cells) have been found to be involved in human malignancies, however, the possible implication of Tregs in regulating generation and differentiation of Th17 cells in malignant pleural effusion remains to be elucidated. METHODS The numbers of both CD39(+)Tregs and Th17 cells in malignant pleural effusion and pe...

تقوایی, ترنگ, حسین نتاج, هادی, حسینی, وحید, خلیلی, علی, عابدیان کناری, سعید, محمدنیا افروزی, موسی, ملکی, ایرج,

Background and purpose: Crohn disease (CD) is an autoimmune disorder in which a failure of tolerance to the intestinal antigens plays a pivotal role in the pathogenesis of this disease. Treg cells control immune responses to self and foreign antigens and have an important role in maintaining self-tolerance. In this study we evaluated the frequency of Tregs in the peripheral blood of patients wi...

Journal: :Results in immunology 2011
Anna Rydén Maria Faresjö

Increased attention has been drawn to the important role played by regulatory T-cells (Treg) in immune homoeostasis. However, the small numbers of Tregs make them elusive to study. We investigated the cryostability of Tregs and whether they can be expanded from cryopreserved peripheral blood mononuclear cells (PBMCs). Further, to elucidate if there is a difference in ex-vivo frequency or in vit...

Journal: :Journal of immunology 2008
Gui-Jun Wang Yuelong Liu Aijian Qin Spandan V Shah Zhong-bin Deng Xiaoyu Xiang Ziqiang Cheng Cunren Liu Jianhua Wang Liming Zhang William E Grizzle Huang-Ge Zhang

Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELP...

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