Robustness to mutations and noise has been shown to evolve through stabilizing selection for optimal phenotypes in model gene regulatory networks. The ability to evolve robust mutants is known to depend on the network architecture. How do the dynamical properties and state-space structures of networks with high and low robustness differ? Does selection operate on the global dynamical behavior o...

Regulatory evolution has frequently been proposed as the primary mechanism driving morphological evolution. This is because regulatory changes may be less likely to cause deleterious pleiotropic effects than changes in protein structure, and consequently have a higher likelihood to be beneficial. We examined the potential for mutations in trans acting regulatory elements to drive phenotypic cha...

Nowadays the control of stator voltage at a constant frequency is one of the traditional and low expense methods in order to control the speed of induction motors near its nominal speed. The torque of induction motor is a nonlinear function of the firing angle, phase angle and speed. In this paper the speed control of induction motor regarding various load torque and under different conditions ...

Large networks, such as the electric grid, are controlled by multitudes of agents, such as relays, voltage regulators and optimization programs. To make such agents more effective, we suggest: a common framework for specifying tasks, a collaborative net by which neighboring agents can exchange information, and a protocol to ensure that the collaborations will be helpful. We propose a basic prot...

In this paper the H2-optimal control problem of systems with multiple i/o delays is presented. The problem is first converted to an equivalent H2 regulator problem with multiple delays. The idea is to view the regulator problem in time-domain as a linear quadratic regulator problem with multiple input delays. It is shown that the rational part of the optimal controller has the same dimension as...

When growth regulatory genes are damaged in a cell, it may become cancerous. Current technological advances in the last decade have allowed the characterization of the whole genome of these cells by directly or indirectly measuring DNA changes. Complementary analyses were developed to make sense of the massive amounts of data generated. A large majority of these analyses were developed to const...

Three cosmids previously shown to contain information necessary for the expression of uptake of hydrogenase in Rhodobacter capsulatus were found to be present in a cluster on the chromosome. Earlier genetic experiments suggested the presence of at least six genes essential for hydrogenase activity that are now shown to be in a region of approximately 18 kb that includes the structural genes for...

Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine- amide (RFamide)-related peptides (RFRPs), indicated a similar function...

This paper presents the optimal regulator for a linear system with multiple state delays and a quadratic criterion. The optimal regulator equations are obtained using the maximum principle. Performance of the obtained optimal regulator is verified in the illustrative example against the best linear regulator available for linear systems without delays. Simulation graphs demonstrating better per...