The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...

When T cells encounter foreign antigen and appropriate costimulatory signals from professional antigen-presenting cells (APCs), they initiate a coordinated program of rapid proliferation and differentiation, leading to the development of activated T cells with specific effector functions tailored toward pathogen clearance or control. One of the fundamental programs that underpin T-cell prolifer...

expansin proteins are a type of cell-wall loosening proteins which able to cell wall expansion in ph-dependent manure without hydrolyze of main cell wall structures. the arabidopsis expa1 exhibit guard cell specific expression and trigger the stomatal movements. the objectives of this study were to transfer the atexpa1 gene into tobacco plants and evaluate their phonotypic effects on transforme...

Salt and drought stress are important abiotic factors that negatively affect plant growth yield. To understand how these metabolism at the cellular level, we analyzed cation concentrations expression of extracellular proteins, as well their functions types. Cells industrially halophyte sugar beet were exposed to 300 mM NaCl 600 mannitol stressors in modified Gamborg B5 liquid medium (PG0). Seve...

Given the opposing responses reported for bisphenol A (BPA) in terms of induction obesogenic effects and impaired lipid metabolism, increasing use F (BPF), relatively low information available regarding bis(3-chloro-2- hydroxypropyl) ether (BADGE·2HCl) aquatic organisms, this work aims to zebrafish liver cell line (ZFL) as an alternative model characterize toxicity metabolism disruptive potenti...

The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...

Background: Culture media enrichment through the addition of protein hydrolysates is beneficial for achieving higher protein expression. Methods: In this study, designing the optimum mixture of four soy and casein-derived hydrolysates was successfully performed by design of experiment and specific productivity increased in all predicted combinations. Protein profile of recombinant CHO (rCHO) ce...

ige-mediated cell signaling, induced by cross-linking of high affinity receptor for ige (fcεri) in the presence of antigen (ag), is a well known mechanism described for mast cell activation in allergy and hypersensitivity reactions, which induces a spectrum of cellular responses such as secretion and up-regulation of cell surface fcεri. although for several years  ige  binding  to  fcεri  was  ...