Despite its evolutionary conservation and functional importance, little is known of the signaling pathways that underlie development of the hypothalamus. Although mutations affecting Nodal and Hedgehog signaling disrupt hypothalamic development, the time and site of action and the exact roles of these pathways remain very poorly understood. Unexpectedly, we show here that cell-autonomous recept...

Ethnoracial residential segregation is a complex, multiscalar phenomenon with immense moral and economic costs. Modeling the structure and dynamics of segregation is a pressing problem for sociology and urban planning, but existing methods have limitations. In this paper, we develop a suite of methods, grounded in information theory, for studying the spatial structure of segregation. We first a...

Although regionalism is a long-standing feature in international relations only since the 1960s and more emphatically since late 1980s scholars have shown a dedicated interest in the phenomenon. The literature is nonetheless disarticulated. This article takes one step back to take two steps forward. First it clarifies commonly used terms in the field as region, regionalism and regionalization a...

Drosophila, Wnt, FGF, Jak/Stat, Rho, Rac, RhoGEF, Pebble, Naked Cuticle The site for the latest installment of the Fly Meeting (March 7–11) was downtown Philadelphia. The conference offered an illustration of all that is great about the Drosophila field bringing together evolutionary biologists, immunologists and everyone in between. Here I will provide a small sample of several advances from t...

We show that the oscillatory driving of crystal surfaces can induce pattern formation or smoothening. Depending on driving conditions, step bunching and meandering, mound formation, or surface smoothening may be seen in the presence of a kinetic asymmetry at the steps or kinks. We employ a step model to calculate the induced mass flux along misoriented surfaces, which accounts for surface dynam...

background: avoidable mortality (am) is one of the most important health indicators (hi) and represents the quality of care in a hospital.objective: this study measured the efficacy of a training program for a hospital healthcare staff to reduce am.methods: this epidemiological study on community intervention analyzed time-series data on hi by semesters from 2008 to 2015. the pre-intervention p...

Abstract Regionalization has been a defining feature of European politics since the 1970s. Previous work studied political drivers movements competences to subnational level, including role citizens’ preferences. Yet, we still know little about how these new divisions between government levels have impacted development public opinion this division. The article builds on literature policy feedba...