interference with microtubule polymerization results in cell cycle arrest leading to cell death. colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. a set of 3',4'-bis (substituted phenyl)-4'h-spiro[indene-2,5'-isoxazol]-1(3h)-one derivatives with known antiproliferative activities were evaluated for their t...

The paper reviews how we can learn from the past about climate-human-environment interactions at the present time, and in the future. It focuses on data sources for environmental change at local/regional and regional/global spatial scales, and shows the scope and limitations of each. It reviews alternative methods for learning from the past, including the increasing use of simulation models. Th...

Regional and local weather patterns are strongly affected by macroclimatic phenomena. In tropical South America, hydroclimatological behavior is affected by such factors as the meridional oscillation of the Intertropical Convergence Zone, the dynamics of Pacific and Atlantic oceans, the Amazon jungle, and the orographic barriers of the Andes mountains. Interactions between these factors at diff...

This paper tries to address the impact of the Shanghai Cooperation Organization on Central Asian security. This organization was established on April 26, 1996 to settle security and territorial disputes between China and Russia and Central Asian countries (other than Uzbekistan and Turkmenistan). After the accession of Uzbekistan to this assembly, the level of the organization was promoted, and...

This paper tries to address the impact of the Shanghai Cooperation Organization on Central Asian security. This organization was established on April 26, 1996 to settle security and territorial disputes between China and Russia and Central Asian countries (other than Uzbekistan and Turkmenistan). After the accession of Uzbekistan to this assembly, the level of the organization was promoted, and...

Railway transportation plays an important role in the economic development of Iran. National Iranian Railways includes fifteen regional railways which operate independently, but under the supervision of National Iranian Railways Company. Evaluating the efficiency of regional railways is an important issue in Iran and is one of the bases for budget and resource allocation for further developmen...

Arthropods are an important component of grassland systems, contributing significantly to biodiversity and ecosystem structure and function. Climate, fire, and grazing by large herbivores are important drivers in grasslands worldwide. Arthropod responses to these drivers are highly variable and clear patterns are difficult to find, but responses are largely indirect with respect to changes in r...

This paper focuses attention on the relevance of the notion of sustainable development in a regional context and the use of models in analyzing sustainable development. The paper discusses first the notion of sustainable development, linking socio-economic, ecological and political-ethical elements. Time and space prove to be important dimensions of sustainable development, in both distribution...

Inferring biotic interactions from functional, phylogenetic and geographical proxies remains one great challenge in ecology. We propose a conceptual framework to infer the backbone of biotic interaction networks within regional species pools. First, interacting groups are identified to order links and remove forbidden interactions between species. Second, additional links are removed by examina...