Calcitonin gene-related peptide, a 37-amino-acid neuropeptide, has been shown to be widely distributed in periadventitial nerves throughout the cardiovascular system, particularly in association with coronary arteries. In vivo and in vitro studies have demonstrated that calcitonin gene-related peptide possesses potent vasodilator properties. Circulating calcitonin gene-related peptide is derive...

1. Hoedt-Rasmussen K, Skinhoj E, Paulson O, et al: Regional cerebral blood flow in acute apopiexy. Arch Neurol (Chicago) 17: 271-281, 1967 2. Cannon PJ, Sciacca RR, Brust JCM, et al: Measurement of regional cerebral blood flow with '"Xe and a multiple-crystal scintillation camera. Stroke 5: 371-383, 1974 3. Donley RF, Sundt TM, Anderson RE, et al: Blood flow measurements and the look through ar...

OBJECTIVE Determining the blood flow through intra and extra-cranial arteries during neck extension may be helpful but is a controversial issue. We aimed to elucidate the changes in cerebral blood flow related to head positioning during thyroid surgery by carotid Doppler examination and regional oxygen saturation variations. METHODS Thirty patients were recruited to the study. Patients were p...

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4...

The Relationship of Regional Cerebrovascular CO, Reactivity to Blood Pressure and Regional Resting Flow • Cerebrovascular CO 2 reactivity (the change in cerebral blood flow per mm Hg change in Pa c02) is shown to be directly related to resting flow and inversely related to blood pressure for regional as well as for mean CBF data. Both regional and mean CO 2 reactivity therefore are proportional...

Despite the heterogeneous distribution of regional pulmonary perfusion over space, local perfusion remains stable over short time periods (20-100 min). The purpose of this study was to determine whether the spatial distribution of pulmonary perfusion remains stable over longer time periods (1-5 days). Regional blood flow was measured each day for 5 days in five awake standing dogs. Fluorescent ...

A two-site middle cerebral artery occlusion model in rabbits was developed. Platinum electrodes served for simultaneous recordings of regional cerebral blood flow, auditory evoked potentials, and electroencephalogram in the left and right auditory cortex and in the left medial geniculate body. Auditory evoked potentials and regional cerebral blood flow were also recorded in the subcortical whit...

OBJECTIVES Aortic arch disease can be treated with hybrid repair (extra-anatomic bypass plus placement of aortic endoprostheses), but there is controversy about whether a bypass from one relatively small vessel will provide adequate blood flow to the entire brachiocephalic system. We, therefore, compared flow volumes before and after hybrid repair. METHODS We reviewed the records of 16 patien...