Ziel/Aim Restoration of iodine incorporation (redifferentiation) was achieved in previously radioiodine-refractory, unresectable thyroid carcinoma by mitogen-activated protein kinase (MAPK) inhibition. However, redifferentiation unsatisfactory BRAFV600E mutated (BRAF-MUT) thus far. Here we assess safety and efficacy therapy through genotype-guided MAPK-modulation patients with BRAF-MUT or wild ...

BACKGROUND Corticosteroids have been used for refractory Mycoplasma pneumoniae pneumonia and have beneficial effects. The aim of this study was to identify the biomarkers for predicting refractory M. pneumoniae pneumonia in a timely fashion to initiate steroid therapy. METHODS This was a prospective cohort study of children with M. pneumoniae pneumonia admitted to the Children's Hospital of F...

A fundamental problem in studying the latent-to-lytic switch of Epstein-Barr virus (EBV) and the viral lytic cycle itself is the lack of a culture system fully permissive to lytic cycle induction. Strategies to target EBV-positive tumors by inducing the viral lytic cycle with chemical agents are hindered by inefficient responses to stimuli. In vitro, even in the most susceptible cell lines, mor...

The word, super-refectory is coined recently in status epilepticus (SE) when the seizures continue unabated for a day or more, despite rigorous management , leading to subsequent neuronal injury, most of the times and even death [1]. The SuperRefractory Status Epilepeticus is a rare but not uncommon type of ongoing seizure activity and the exact pathophysiology is still not yet studied well. Th...

objective refractory convulsive status epilepticus (se) which does not respond to first line drugs (benzodiazepines, phenytoin and phenobarbital) heralds an emergency condition in pediatric neurology which can cause irreparable brain damage. there is no consensus on the choice of drug treatment for refractory generalized  convulsive status epilepticus in children. lidocaine is a valuable forgot...

Nine laboratory populations and one field population of the snail host Biomphalaria glabrata were compared with respect to their electrophoretic patterns for acid phosphatase (AcP) and with their susceptibility to Schistosoma mansoni infection. A strong correlation (r = 0.98) was noted between the frequency of the isoenzymes AcP2-S and Acp2-F observed in the populations and the level of snail s...

The cycle length dependence of the action potential duration and the effective refractory period of the right ventricular endocardium were investigated in 24 patients undergoing electrophysiologic studies for suspected ventricular tachycardia. The action potential duration at 90% repolarization and the effective refractory period at twice diastolic threshold strength were measured at the same c...

The use of sintered CaO as a refractory material is not uncommon. Refractory material based on lime as the lining of the Bessemer converter was applied for the first time in 1875 in order to carry out desulphuring and dephosphoring of the molten pig iron. Due to interaction of the porous burned CaO with the atmospheric moisture during dead time followed by damage and disintegration of this case...