Polymorphisms within one-carbon metabolism genes have been largely studied in relation to cancer risk for the function of this pathway in nucleotide synthesis and DNA methylation. Aims of this study were to explore the possible link among several common functional gene polymorphisms within one-carbon metabolism and survival rate in primary liver cancers, i.e., hepatocellular carcinoma and chola...

Inter-individual variation in patterns of DNA methylation at birth can be explained by the influence of environmental, genetic and stochastic factors. This study investigates the genetic and non-genetic determinants of variation in DNA methylation in human infants. Given its central role in provision of methyl groups for DNA methylation, this study focuses on aspects of folate metabolism. Globa...

Folate is an important nutrient for cell growth and division in all organisms. Many microorganisms including prokaryotes and eukaryotes can synthesize their own folate while humans cannot. To assimilate folate into the cell a folate transporter is required for uptake through the cell membrane. Three types of folate transporters are known to exist in humans to facilitate the uptake of folate: Re...