BACKGROUND The efficacy of many preparations for topical use in herpes infections have remained rather disappointing. The development of new antiviral drugs, especially herbal preparations, thus remains desirable. In a screening study with plant extracts, a rhubarb root extract and a sage extract showed a promising activity. OBJECTIVE The efficacy of a combined topical preparation with rhubar...

OBJECTIVE(S) Infection with the human T-cell lymphotrophic virus type-I (HTLV-I) is endemic in Mashhad, Iran. In our research we evaluated the relation between exposure to this infection and the occurrence of dermatologic manifestations. MATERIALS AND METHODS 100 blood donors, who were seropositive but asymptomatic for infection with HTLV-I, were selected as case group. They were identified b...

BACKGROUND There are 3 new topical treatments for herpes labialis that have either been approved by the US Food and Drug Administration (penciclovir cream [Denavir] and n-docosanol cream [Abreva]) or recently undergone extensive clinical evaluation (acyclovir cream). The relative efficacy of these products is unknown. OBJECTIVE To compare the efficacy of penciclovir cream, acyclovir cream, n-...

BACKGROUND Given the limitations of current antiviral therapies, safer and more effective approaches to the management of recurrent herpes labialis (RHL) are needed. METHODS A patient with a 23-year history of RHL and 14 healthy individuals were studied. The patient applied imiquimod to distant healthy skin for 3 weeks. Peripheral blood (PB) samples were collected from the patient during trea...

BACKGROUND Hydrocolloid technology has been proven effective in treating dermal wounds. A previous study showed that a newly developed thin hydrocolloid patch [Compeed cold sore patch (CSP)] provided multiple wound-healing benefits across all stages of a herpes simplex labialis (HSL) outbreak. METHODS An assessment of CSP efficacy and safety was conducted in an international, multicentre, ass...

This editorial is a request for clinician researchers to report on speech recovery in cases of Wernicke’s Aphasia post Herpes Simplex Viral Encephalitis. The literature, while it contains detailed case histories of Wernicke’s cases post stroke, does not contain extensive material on speech recovery post encephalitis. A case report is now in progress, but there is little current and detailed lit...