Recombinant human interleukin-1 (IL-I) ac and , were found to activate a latent cytosolic form of the transcription factor NFKB in rat C6 glioma. IL-if? was 10 times more potent than IL-1 a for this activity and both were inhibited by the IL-1 receptor antagonist. The activation was detectable from 20 min and remained sustained for up to 24 h. The electrophoretic mobility of the activated compl...

Background Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease characterized by recurrent episodes of cutaneous, abdominal and laryngeal edema. Bradykinin is the mediator of increased vascular permeability and edema formation. Treatment of HAE attacks in Italy is based on the administration of human C1 inhibitor or bradykin receptor antagonist. A recombinant huma...

Stroke Plasminogen Activator Treatment Alone and in Combination in a Rat Embolic Model of Effects of a Selective CD11b/CD18 Antagonist and Recombinant Human Tissue Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR....

recombinant human interferon alpha 2a (rhifn α -2a) production and cell growth were monitored in a set of genetically modified e. coli strains (msd1519, msd1520, msd 1521, msd 1522, msd 1523) producing rhifn α -2a. the growth was followed at od 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (pyms) of cell biomass and recombinant protein production was determined...

Abstract Study question Is there a difference, in terms of ovarian yield and sensitivity, comparing progestin-primed protocols (PPOS) to GnRH antagonist (GnRH-ant) using different follitropin? Summary answer PPOS is an effective choice, with both follitropis. Nevertheless, could improve sensitivity FSHu increasing the number oocyte without compromising quality. What known already The use new st...

background: since increased lh in the early follicular phase in pcos patients especially in gnrh antagonist protocol could be associated with reduced oocyte quality and pregnancy and impared implantation. the current study was conducted to determine art outcomes in gnrh antagonist protocol (flexible) and long gnrh agonist protocol and compare them with adding gnrh antagonist in gnrh antagonist ...

the effect of short term usage of gnrh antagonist as pretreatment on superovulation in goats was evaluated. statistical analysis was performed using t-test and showed that usage of gnrh antagonist as pretreatment can improve number of recovered embryos (p0.05). this study showed that usage of gnrh antagonist can improve superovulatory response in term of embryo recovery in goats .this study sho...

Abstract Study question How can stimulation of corpus luteum in the luteal phase with human chorionic gonadotropin (hCG) improve obstetric and perinatal outcomes? Summary answer There is currently no evidence that use hCG as an alternative treatment for luteal-phase support (LPS) improves outcomes. What known already are different approaches providing LPS, although none have shown differences p...

Topical glucocorticoids are conventionally used to treat psoriasis, but such treatment provides a short-term effect, and may cause various complications during long-term usage. A detailed study of the immunopathogenesis psoriasis has made it possible use bioengineered drugs that block main cytokines. It been shown IL-36 plays an important regulatory role in pathogenesis psoriasis. The aim was t...