In order to study the influence of both dose and application frequency of tumor-promoting agents on tumor development, we conducted a large-scale mouse skin two-stage carcinogenesis experiment. The back skins of 1110 CD-1 mice were painted once with 50 micrograms benzo(a)pyrene. These mice were divided into 24 groups according to subsequent schedules of 12-O-tetradecanoylphorbol-13-acetate (TPA...

Assessment of skin dose delivered to patients from radiotherapy x-ray beams should be performed both inside and outside the prescribed treatment fields. A multilayer Gafchromic film detector which has high sensitivity for detection of radiation can be used to measure skin dose in a two-dimensional map over the skin surface if required. This is an advantage over other detectors, which only provi...

Patient dosimetry studies in diagnostic radiology in Nigeria have been on measurement of entrance skin dose and effective dose. Another important and easy to measure radiation dose descriptor that could be used to assess patient dose in radiological procedures is dose area product (DAP). Knowledge of DAP with location and projection of X-ray beam allows direct calculation of organ dose and effe...

A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy...

introduction: occupational exposure to ionizing radiation due to medical activities (both diagnostic and therapeutic procedures) has increased sharply in recent years. among the occupationally exposed workers in these fields, those most affected by this increased exposure to ionizing radiation are nuclear medicine workers. in this study, annual average effective dose, annual collective effectiv...

AIMS The aim of this study was to evaluate whether a real-time (RT) colour pictorial radiation dose monitoring system reduces patient skin and total radiation dose during coronary angiography and intervention. METHODS AND RESULTS Patient demographics, procedural variables and radiation parameters were recorded before and after institution of the RT skin dose recording system. Peak skin dose a...

Aim: Thermoplastic immobilization devices are used in head and neck radiotherapy to increase precision of treatment delivery. However, there is concern about increase in radiation induced skin morbidity with the use of such devices. This study was conducted with an aim to evaluate any increase in clinically observed skin reactions with the use of thermoplastic immobilization devices. Materials ...

In recent years, specially designed patches containing beta emitters have been developed for contact brachytherapy of skin lesions. The aim of the present work was to evaluate the biological effects of the (32)P-patch on the skin of Sencar mice as a result of a brachytherapy treatment. For this purpose, a (32)P-patch was prepared with Chromic (32)P-phosphate and silicone and the classical model...