Post-transcriptional base modifications are important to the maturation process of transfer RNAs (tRNAs). Certain modifications are abundant and present at several positions in tRNA as for example the dihydrouridine, a modified base found in the three domains of life. Even though the function of dihydrourine is not well understood, its high content in tRNAs from psychrophilic bacteria or cancer...

Objective: To evaluate the presence of flow by Doppler ultrasound (DUS) in the wrist and finger joints (carpometacarpal 1 (CMC1), metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints) of healthy controls. Methods: Twenty seven healthy volunteers (15 women, 12 men; mean age 45 years, range 18–93) with a total of 324 joints were examined by DUS. The synovial vascularisation was de...

Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently ...

OBJECTIVE In this pilot study, the effect of sildenafil on digital ulcer (DU) healing and related clinical symptoms was analysed. METHODS A total of 19 patients with systemic sclerosis (SSc) were treated with maximally tolerated sildenafil doses up to 6 months. Primary outcome was the healing of DUs. Changes in other clinical symptoms were also evaluated. RESULTS In all, 49 DUs were present...

Arteriovenous graft (AVG) a. Regular Access Blood Flow (Qa) or Doppler ultrasound stenosis (DUS) screening increases the detection of AVG stenosis compared to dynamic venous pressure (DVP)/clinical examination. (Level II evidence) b. Regular Qa screening with pre-emptive angioplasty does not reduce AVG thrombosis or prolong AVG survival. (Level I & II evidence) c. Whether regular DUS screening ...

background and objectives: kerman province, especially city of bam in the southeast part of iran, is epidemics for dry type cutaneous leishmaniasis (dtcl). this study was conducted to compare the effect of different treatments on parasite dna load following therapies using real-time pcr method. materials and methods: fifteen patients were divided into three groups under therapy with intralesio...

objectives: human cytomegalovirus (cmv) is a major life-threatening pathogen for hematopoietic stem cell transplant recipients. specific tests are used for the diagnosis and monitoring of cmv infection in transplant patients. this study evaluates the performance of pp65 antigenemia and qualitative pcr assays for monitoring cmv in such patients. methods: we analyzed 179 clinical samples from 41...