The O-alkylation of carboxylic acids with diazo compounds provides a means to esterify carboxylic acids in aqueous solution. A Hammett analysis of the reactivity of diazo compounds derived from phenylglycinamide revealed that the (p-methylphenyl)glycinamide scaffold has an especially high reaction rate and ester/alcohol product ratio and esterifies protein carboxyl groups more efficiently than ...

This study analyzed factors that influence the ignition delay characteristics of n-heptane/methane-blended fuel. The effects chemical species, exhaust gas recirculation rate, compression ratio, cool/hot flames, and combustion chamber conditions (temperature, pressure, O2 concentration) were determined using CHEMKIN Pro. experiment for verification 550–1000 K at 15 bar with 50% H2/50% CH4 main r...

BACKGROUND AND PURPOSE Limited data exist to recommend specific cerebral perfusion pressure (CPP) targets in patients with intracerebral hemorrhage. We sought to determine the feasibility of brain multimodality monitoring for optimizing CPP and potentially reducing secondary brain injury after intracerebral hemorrhage. METHODS We retrospectively analyzed brain multimodality monitoring data ta...

Background and Objective: Alzheimer’s disease (AD) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. With regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of Alzheim...

background: the risk of developing tuberculosis is high among chronic hemodialysis patients. the tuberculin skin test (tst) has been in use for diagnosing latent tb, but few data are available on tst in hemodialysis patients. objective: this study was done to identify the tst reactivity and frequency of booster effect in serial tst among hemodialysis patients. methods: a total of 100 patients i...

BACKGROUND Cilostazol overcomes high on-treatment platelet reactivity (HTPR) and reduces adverse cardiovascular (CV) outcomes after percutaneous coronary intervention (PCI). However, the role for triple antiplatelet therapy (TAPT) with cilostazol in addition to aspirin and clopidogrel after PCI is not well defined. METHODS We conducted a MEDLINE/EMBASE/CENTRAL search for randomised trials, un...