Obesity is a worldwide public health concern, and prevalence in the United States continuously increasing. Treatment of obesity ranges from dietary approaches to gastric surgery; there no one-size-fits-all approach. In recent years, ketogenic diet (KD) has become popular approach for weight loss metabolic promotion. The main mechanism caused by this promote body use fat as its primary form ener...

OBJECTIVE Galunisertib (LY2157299 monohydrate), an inhibitor of the transforming growth factor β (TGFβ) pathway, is currently under investigation in several clinical trials involving multiple tumor types. The primary objective of this study was to assess relative bioavailability of two new galunisertib formulations developed using the roller compaction (RC) dry-milled (RCD) and RC slurry-milled...

Prolonged mechanical ventilation (MV) results in oxidative damage in the diaphragm; however, it is unclear whether this MV-induced oxidative injury occurs rapidly or develops slowly over time. Furthermore, it is unknown whether both soluble (cytosolic) and insoluble (myofibrillar) proteins are equally susceptible to oxidation during MV. These experiments tested two hypotheses: 1). MV-induced ox...

We aimed to investigate whether periconceptional maternal folate status affects human embryonic cerebellar size and growth trajectories. In a prospective periconceptional cohort participants filled out questionnaires and received weekly transvaginal 3D-ultrasounds between 7+0 and 12+6 weeks gestational age (GA). Viable non-malformed singleton pregnancies were selected for cerebellar measurement...

Despite the difficulty in fabrication, resonant tunnelling diodes (RTD) have found a great deal of usage in the analogue, digital and mixed signal realms as a means of increasing the speed of signal processing circuitry, or in reducing the static power dissipation in the circuitry. Nevertheless, RTDs suffer from their non-planar structure. One possible solution is a planar diode, which operates...

Thepurpose of this study was to determine the link between induction voltages from various electrical loads. We used a residual current device (RCD) circuit that operates with capacitor as DC voltage reading tool. The reads value o

Abstract We prove pointwise and $$L^{p}$$ L p -gradient comparison results for solutions to elliptic Dirichlet problems defined on open subsets of a (possibly non-smooth) space with positive Ricci curvature (more precisely an $${{\,\mathrm{RCD}\,}}(K,N)$$ <mm...

With great interest, we read the relevant results of a randomised clinical trial designed to compare conservative and surgical approach for treating rotator cuff disease (RCD), leading cause shoulder pain disability in adult’s population. The study highlighted superiority surgery, by means (Visual Analogue Scale) function (Constant Murley Score) improvement after 2 years, patients with full-thi...