نتایج جستجو برای: rbl 2h3

تعداد نتایج: 1142  

2012
H Schleifer B Doleschal M Lichtenegger R Oppenrieder I Derler I Frischauf TN Glasnov CO Kappe C Romanin K Groschner

BACKGROUND AND PURPOSE Pyrazole derivatives have recently been suggested as selective blockers of transient receptor potential cation (TRPC) channels but their ability to distinguish between the TRPC and Orai pore complexes is ill-defined. This study was designed to characterize a series of pyrazole derivatives in terms of TRPC/Orai selectivity and to delineate consequences of selective suppres...

Journal: :Journal of immunology 2002
Charlotte M Vines Mei Xue Diane C Maestas Daniel F Cimino Eric R Prossnitz

One of the major functions of the N-formyl peptide receptor (FPR) is to mediate leukocyte degranulation. Phosphorylation of the C-terminal domain of the FPR is required for receptor internalization and desensitization. Although arrestins mediate phosphorylation-dependent desensitization, internalization, and initiation of novel signaling cascades for a number of G protein-coupled receptors, the...

2012
Kshitij Gupta Hariharan Subramanian Andreas Klos Hydar Ali

BACKGROUND Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important for their desensitization. Using shRNA-mediated gene silencing strategy, we have recently shown that GRK2, GRK3 and β-arrestin-2 promote C3a receptor (C3aR) desensitization in human mast cells. We also demonstrated that β-arre...

Journal: :Blood 1996
T Tsujimura M Morimoto K Hashimoto Y Moriyama H Kitayama Y Matsuzawa Y Kitamura Y Kanakura

A peculiar point mutation results in constitutive activation of c-kit receptor tyrosine kinase (KIT) in three different tumor mast cell lines; ie, the HMC-1, P-815, and RBL-2H3. Because constitutive activation of KIT was also observed in the FMA3 mouse mastocytoma cell line, we investigated the molecular mechanism. Sequencing of the whole coding region of the c-kit showed that the point mutatio...

2015
Ali Munaim Yousif Michele Minopoli Katia Bifulco Vincenzo Ingangi Gioconda Di Carluccio Francesco Merlino Maria Letizia Motti Paolo Grieco Maria Vincenza Carriero

The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized master regulator of cell migration and uPAR88-92 is the minimal sequence required to induce cell motility. We and others have previously documented that the uPAR88-92 sequence, even in the form of synthetic linear peptide (SRSRY), interacts with the formyl peptide receptor type 1 (FPR1), henceforth inducing ...

Journal: :Biosensors & bioelectronics 2007
Yuhki Yanase Hidenori Suzuki Tomoko Tsutsui Ichiro Uechi Takaaki Hiragun Shoji Mihara Michihiro Hide

Living cell reactions are detected as changes of the angle of resonance (AR) for surface plasmon resonance (SPR). Since SPR reflects the events in the field of evanescence, cells need to be fixed on the sensor chip. In this study, we developed methods to fix living cells on a gold surface and to recover adherent cells from the culture dish, preserving their functions to be analyzed by SPR. Huma...

Journal: :The Biochemical journal 2006
Mark Chalmers Michael J Schell Peter Thorn

The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not understood. Using immunocytochemistry, live-cell imaging and heterologous expression of ER membrane proteins we have investigated IP3R cl...

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