Elevated glucose level and low pH have been shown to increase red blood cell (RBC) rigidity. This increased rigidity has been proposed as one factor which mediates the tumor blood flow (TBF) reduction during hyperglycemia by (a) causing RBC entrapment and hence increasing geometric resistance and (b) increasing viscous resistance to blood flow. However, due to the inability to measure these res...

In sickle cell anemia, dehydrated erythrocytes (SS RBC) are involved in the propagation of the vasoocclusive process, which results in the most severe complication in sickle cell disease (e.g. stroke). Deoxygenation leads to red cell dehydration, and hence increases the rate of hemoglobin S (HbS) polymer formation, which subsequently sickles the cell and retards RBC transit through the microvas...

concentrations were significantly different between HbSS and HbSC patients (P 5 0.016), and between HbSS patients and HbAA controls (P ,0.0001), as determined by the Student t-test. Our observation is consistent with the establishment of RBC folate concentrations during hemopoiesis and a subsequent decrease during circulation, causing higher RBC folate concentrations in young circulating RBCs (...

Individuals that become immunized to red blood cell (RBC) alloantigens can experience an increased rate of antibody formation to additional RBC alloantigens following subsequent transfusion. Despite this, how an immune response to one RBC immunogen may impact subsequent alloimmunization to a completely different RBC alloantigen remains unknown. Our studies demonstrate that Kell blood group anti...

Anaemia and RBC (red blood cell) transfusion may be associated with worse clinical outcomes, especially with longer blood storage duration prior to transfusion. The mechanisms underlying these harmful effects are unknown. RBCs have been proposed to buffer plasma S1P (sphingosine 1-phosphate), a lysophospholipid essential for the maintenance of endothelial integrity and important in the regulati...

Europe is a densely populated region that is a significant global source of black carbon (BC) aerosol, but there is a lack of information regarding the physical properties and spatial/vertical distribution of rBC in the region. We present the first aircraft observations of sub-micron refractory BC (rBC) aerosol concentrations and physical properties measured by a single particle soot photometer...

The normal red blood cell (RBC) membrane is remarkable for its durability (eg, preservation of permeability barrier function) despite its need to remain deformable for the benefit of microvascular blood flow. Yet, it may be hypothesized that the membrane's tolerance of deformation might be compromised under certain pathologic conditions. We studied this by subjecting normal RBC in viscous suspe...

objective: this study was designed to investigate rbc indices and hba2 levels in parents of major beta-thalassemia patients to detect possible silent beta- thalassemia carriers and examine its potential impact on the premarital genetic counseling. materials and methods: this cross sectional study was performed at children medical center from 2004 to 2006. after genetic counseling and getting in...

In this issue of Blood, Kaul et al1 report that stimulation by platelet-activating factor (PAF) of artificially perfused rat mesocecum ex vivo promotes the adhesion of human sickle red blood cells (SS RBC) to postcapillary endothelium. Notably, this adhesive interaction was blocked by two different monoclonal antibodies (MoAbs) to endothelial aVb3 integrin receptor, with resulting improvement i...

because the 4N1K peptide of thrombospondin-1 was applied at 3 10 mol/l, a concentration that exceeds the thrombospondin-1 concentration in plasma by a factor of 10 to 10 [6]. Correspondingly, Head et al. [7] found that the 4N1K peptide at the very same high concentration (50 g/ml) binds to CD47 without the need to impose a conformational change by e.g. oxidation. Moreover, incubation of RBC wit...