نتایج جستجو برای: razy 251

تعداد نتایج: 6748  

ژورنال: پژوهش در پزشکی 2015

Upper respiratory tract infection (URTI), the most common infectious disease among trained endurance athletes, declines the athletic performance. The aim of this study was to investigate the influence of IL-8 gene polymorphisms on upper respiratory tract infection (URTI) incidence. Materials and Methods: This is a historic cohort study and one hundred healthy elite male athletes were classi...

Journal: :Journal of Investigative Dermatology 2016

Journal: :Learning & memory 2010
Lucas de Oliveira Alvares Douglas Senna Engelke Felipe Diehl Robson Scheffer-Teixeira Josué Haubrich Lindsey de Freitas Cassini Victor Alejandro Molina Jorge Alberto Quillfeldt

The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Ivan Trujillo-Pisanty Giovanni Hernandez Ian Moreau-Debord Marie-Pierre Cossette Kent Conover Joseph F Cheer Peter Shizgal

There is ample evidence that blockade of CB(1) receptors reduces reward seeking. However, the reported effects of CB(1) blockade on performance for rewarding electrical brain stimulation stand out as an exception. By applying a novel method for conceptualizing and measuring reward seeking, we show that AM-251, a CB(1) receptor antagonist, does indeed decrease performance for rewarding electrica...

Journal: :Pharmacology, biochemistry, and behavior 2010
K S Sink K N Segovia L E Collins E J Markus V K Vemuri A Makriyannis J D Salamone

The effects of CB1 antagonist/inverse agonists on the acquisition and consolidation of conditioned fear remain uncertain. Recent studies suggest that the CB1 antagonist/inverse agonist AM251 affects acquisition or consolidation of both contextual and discretely cued fear memories. AM251 is frequently referred to as a CB1 antagonist; however in vitro signal transduction assays indicate that this...

Journal: :Neuron 2009
Lu Li Kevin J. Bender Patrick J. Drew Shantanu P. Jadhav Emily Sylwestrak Daniel E. Feldman

Type 1 cannabinoid (CB1) receptors mediate widespread synaptic plasticity, but how this contributes to systems-level plasticity and development in vivo is unclear. We tested whether CB1 signaling is required for development and plasticity of the whisker map in rat somatosensory cortex. Treatment with the CB1 antagonist AM251 during an early critical period for layer (L) 2/3 development (beginni...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Camila Scorticati Javier Fernández-Solari Andrea De Laurentiis Claudia Mohn Juan P Prestifilippo Mercedes Lasaga Adriana Seilicovich Silvia Billi Ana Franchi Samuel M McCann Valeria Rettori

Because Delta-9-tetrahydrocannabinol (THC) inhibited luteinizing hormone-releasing hormone (LHRH) in male rats, we hypothesized that the endocannabinoid, anandamide (AEA), would act similarly. AEA microinjected intracerebroventricularly (i.c.v.) decreased plasma luteinizing hormone (LH) at 30 min in comparison to values in controls (P < 0.001). The cannabinoid receptor 1 (CB1-r)-specific antago...

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