background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...

background wound healing is widely discussed in the medical literature. this study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. methods sixteen rats were randomly assigned to one of two groups, each group 8 rats. a deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a st...

background: musculoskeletal pain is a major clinical problem, but researchers lack viable animal models to study this phenomenon. however, formalin injections are widely used to produce tonic and neurogenic nociceptive responses in rodents. rodents can present a potential animal model for pain. objectives: to develop a muscle pain model with intramuscular injection of formalin in rats. material...

We present 870 $\mu$m ALMA polarization observations of thermal dust emission from the iconic, edge-on debris disk $\beta$ Pic. While spatially resolved map does not exhibit detectable polarized emission, we detect at $\sim$3$\sigma$ level when averaging across entire disk. The corresponding fraction is $P_\textrm{frac}$ = $0.51 \pm 0.19$%. position angle $\chi$ aligned with minor axis disk, as...

INTRODUCTION: Although HIV testing is a critical screening and entry point for accessing treatment, programs worldwide are strained by limited resources which require practical cost-effective strategy clients. Screening tools becoming increasingly common given their presumed advantage of efficiency cost-effectiveness in predicting prioritizing clients who most at risk positive.
 
 MET...

background hepatocytes are used as an in vitro model to evaluate drug metabolism. human hepatocyte transplant has been considered as the temporary treatment of acute liver failure. optimization freezing methods is very important to preserve both cell viability and function which are achieved by cryopreservation mostly always. objectives the present study aimed to investigate the cryoprotective ...

In our earlier studies on CCl4 induced acute toxicity model (CCl4 3ml/kg body wt). Abhrak bhasma protects fatty degeneration of liver and associated nephrotoxicity in male albino rats. It had shown to function through production management free radicals (Teli Kanase, 2020a, b). To study further the paths Bhasma mediated protection hepatotoxicity nephrotoxicity, liver, kidney serum lipid content...

objective(s) aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. in the present study different extracts of roots of a. indica were evaluated for their anti­inflammatory, antipruritic and mast cell stabilizing activity. materials and methods anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and ant...