Since its description more than two decades ago as a substrate for botulinum C3 exoenzyme (Didsbury et al, 1989), Rac1 has been one of the most studied small GTPases of the Ras superfamily. Interest in Rac1 exploded in 1992 when Ridley and Hall published their seminal work showing that Rac1 regulates the actin cytoskeleton to promote lamellipodia formation (Ridley et al, 1992). Since that repor...

The concept of a “local” renin angiotensin system (RAS) can mean different things to different people. Its main purpose is to differentiate the “local” RAS operating in tissues from the classical “circulating” RAS, but it is difficult to differentiate between the two systems because of their extensive overlap. The circulating RAS comprises kidney-derived renin acting on liver-derived angiotensi...

BACKGROUND AND AIM: Recurrent aphthous stomatitis (RAS) is a lesion of the oral cavity with an unknown etiology. Several studies have been performed on the role of tumor necrosis factor-alpha (TNF-α) in RAS. The main purpose of this paper was to review TNF-α level and its gene polymorphism in patients with RAS, the factors influencing the production of TNF-α, a...

communicative moves and lexical cohesion patterns (lcps), as mounting evidence shows, are two important indicators in writing and publishing the ras. however, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the ras have not been given due attention to date. having this in mind and based on a sound theoretical framework, at...

statement of the problem: recurrent aphthous stomatitis (ras) is one of the most common lesions in the oral cavity. due to its multifactorial nature, there is no definitive treatment for ras. laser therapy is one of the suggested treatments to reduce patient’s discomfort. purpose: the purpose of the present clinical trial is to assess the effect of low and high level laser therapy on pain contr...

The Ras al Hadd oceanic dipole is a recurrent association of cyclone (to the northeast) and an anticyclone southwest), which forms in summer breaks up at end autumn. It lies near cape, southeast Arabian peninsula. Its size on order 100 km. Along axis this flows intense jet, Had jet. Using altimetric data eddy detection tracking algorithm (AMEDA: Angular Momentum Eddy Detection Algorithm), we de...

pressed at very low levels in normal cells. ARF expresFrom among the cast of thousands that appear to play sion can be directly activated by the transcription factors a role in the regulation of programmed cell death, p53 DMP1 and E2F1, or downregulated by factors such as has emerged as one of the leading stars. p53 is a protein Twist and Bmi1. The induction of ARF following activaof many talen...

In the published version "Paladini et al. reported that aliskiren 300 mg provided a sustained BP-lowering effect beyond the 24-h dosing interval, with a significantly smaller loss of BP-lowering effect in the 24-48 h period after dose than irbesartan 300 mg or ramipril 10 mg [25]". Paladini et al. should be Palatini et al., and the cited reference number should be [10], not [25].. In the senten...