BACKGROUND Atherosclerotic ischemic renal disease is a frequent cause of end-stage renal failure leading to dialysis among the elderly; Its prevalence is inferred from autopsy or retrospective arteriographic studies. This study has been conducted on 269 subjects over 50 with hypertension and/or CRF, unrelated to other known causes of renal disease. METHODS All 269 patients were studied either...

Since the declaration of war on cancer more than 40 years ago, progresses on cancer treatment outcomes have been slow and limited for most part, despite major investments in research and development. However, the realization that cancer is an extremely complex and heterogeneous mixture of diseases, coupled with technological advances in cancer genomics, proteomics, and metabolomics, has led to ...

Determination of RAS and BRAF mutational status is standard-of-care in the management metastatic colorectal cancer (mCRC). Liquid biopsy (LB) a powerful technology to evaluate tumor genetic heterogeneity noninvasive manner. Because RAS-mutations (mut) play major role resistance anti-EGFR-therapy mCRC, serial monitoring RAS-mut with LB may be useful guide treatment. A retrospective observational...

Although formation of urothelial carcinoma of the bladder (UCB) requires multiple steps and proceeds along divergent pathways, the underlying genetic and molecular determinants for each step and pathway remain undefined. By developing transgenic mice expressing single or combinatorial genetic alterations in urothelium, we demonstrated here that overcoming oncogene-induced compensatory tumor bar...

The study investigated whether there was any significant generic difference between the Research Questions (RQs) and Method sections of applied linguistics research articles (RAs) published in international and local Iranian journals. Two hundred applied linguistics RAs (100 from each group) were selected from 5 SSCI-indexed international journals and 5 Iranian Scientific-Research (Elmi-Pazhouh...

Germline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role of the RAS/MAPK pathway in HCM pathogenesis is unclear, we generated a human induced pluripotent stem cell (hiPSC) model for CFCS from three patients with activating BRAF mutations. By cell sorting for SIRPα and CD90, we generated a method to ex...

Recent reports suggest that expression of an activated c-Ha-ros onco gene is associated with cisplatin resistance in NIH-3T3 fibroblasts. To investigate the generality of these observations, cisplatin cytotoxicity was determined in a series of clonal Rat-1 fibroblast and rat ovarian surface epithelial (ROSE) cell lines carrying a zinc-inducible metallothioneinRAST24 fusion gene, MTR4ST24. Cispl...

statement of problem: recurrent aphthous stomatitis (ras) is one of the most common diseases affecting the oral mucosa. many topical and systemic medications used to treat ras have adverse local and systemic effects. chamomill (kamillosan) has been shown to be an effective drug, without any noticeable side effects. purpose: the aim of present study was to assess the efficacy of a chamomill mout...