Background Nodular lymphoid hyperplasia (NLH) of intestine is an extremely rare lymphoproliferative disorder of uncertain etiology. Usually, polyps benign lymphoid tissue are present in the intestinal mucosa. It may present as an asymptomatic or manifest with gastrointestinal symptoms such as abdominal pain, chronic diarrhea, occult bleeding or intestinal obstruction. NLH found in association w...

Acquired hemophilia A (AHA), is a rare bleeding disorder with an incidence of approximately 1 per million/year.The disease is caused by the development of autoantibodies directed against clotting factor VIII and associated with an increased morbidity and mortality. In 50% of cases, FVIII autoantibodies occur in patients lacking any relevant concomitant disease; the remaining cases may be associ...

Chediak-Higashi syndrome (CHS) is a very rare autosomal recessive immunodeficiency disorder characterized by partial albinism, recurrent pyogenic infections, and large granules in all granule-containing cells. The author describes a Thai girl who was the first case of CHS in Thailand. She presented in the accelerated phase of CHS, which leads to repeated infections and bleeding, often resulting...

Polycythemia rubra vera (PV) is a chronic myeloproliferative disorder characterized by elevated red cell mass with an increased risk of both thrombosis and bleeding. Thromboembolic events are the most significant and life-threatening complications associated with PV [1]. Here, we report a rare case of PV presenting as acute myocardial infarction (MI) and briefly discuss the applicability of cur...

Osler-Weber-Rendu disease (OWRD) or Hereditary Hemorrhagic Telangiectasia (HHT) is a rare autosomal dominant disorder that causes muco-cutanesous and visceral vascular dysplasia and results in increased tendency for bleeding [1-4]. Patients with HHT may present with variety of symptoms and management differs accordingly. Epistaxis is the most common symptom of HHT and mucocutaneous telangiectas...

We report a case of a 40 year old man with portal hypertension caused by a splenic arteriovenous fistula that was diagnosed at laparotomy. He presented with bleeding esophageal varices and was initially treated by sclerotherapy. At laparotomy, portal pressure was 40 cmH20 but fell to 20 cm H20 after the fistula was treated with splenectomy. All symptoms disappeared shortly after operation ...

Abstract Multiple myeloma (MM) is a clonal plasma cell disorder that commonly presents with anemia, renal failure, hypercalcemia, and lytic bone lesions. MM also frequently associated thrombotic complications; however, it may rarely present bleeding diathesis. We report case of 42-year-old gentleman relapsed immunoglobulin G lambda who presented epistaxis, gingival bleeding, oozing at the venep...

Along with haemophilia A and B, von Willebrand disease (VWD) and rare bleeding disorders (RBDs) cover all inherited bleeding disorders of coagulation. Bleeding tendency, which can range from extremely severe to mild, is the common symptom. VWD, due to a deficiency and/or abnormality of von Willebrand factor (VWF), represents the most frequent bleeding disorder, mostly inherited as an autosomal ...

Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular disorder characterized by multiple venous malformations involving many organs. BRBNS can occur in various organs, but the most frequently involved organs are the skin and gastrointestinal (GI) tract. GI lesions of BRBNS can cause acute or chronic bleeding, and treatment is challenging. Herein, we report a case of GI BRBNS that ...