Kindling produces enduring neural changes that are subsequently manifest in enhanced susceptibility to seizure-evoking stimuli and alterations in some types of behavior. The present study investigated the effects of dorsal hippocampal (dHPC) kindling on a variety of behaviors to clarify the nature of previously reported effects on spatial task performance. Rats were kindled twice daily with dHP...

The current study examined whether stress reactivity becomes stronger or weaker with age. Daily stress and daily negative affect were modeled using 1,012 subjects from the National Study of Daily Events (NSDE), an 8-day daily diary study. Age ranged from 25 to 74. Data were modeled using within-person HLM techniques. Daily stress and neuroticism interacted in their effect on daily negative affe...

the role of opioid receptor and voltage dependent calcium channels on the kindling induced by the convulsant pentylenetetrazole (ptz) were investigated in the rats. experiment involved 24 rats which were divided into four groups. kindling was established with ptz in subconvulsive dose (37.5 mg/kg i.p.) every 48 h and effects were observed within 20 min using five-point scoring system. all anima...

introduction: the claustrum interconnects with the allocortical and neocortical regions and also projects to the hippocampus and the amygdala. .the role of claustrum in the complex partial seizure is not clear. thus in this study the effect of amygdala lesion on anterior claustrum kindled seizures in rat were investigated. methods: male wistar rats, weighting 250-300 g, were received dc current...

The term kindling refers to the gradual development of epileptiform activity as a result of repeated, spaced stimulations of specific brain regions e.g. amygdala, hippocampus. cerebral cortex. Electrically kindled seizures are a valuable model of human complex partial epilepsy and evidence is accumulating for an involvement of excitatory amino acids (EAAs), and in particular glutamate. in this ...

GABAergic transmission in the mossy fiber (MF) projection of the hippocampus is not normally detected in the rat. However, seizures induce simultaneous glutamatergic and GABAergic transmission in this projection, which coincides with an overexpression of GAD(67) and vesicular GABA transporter (VGAT) mRNA in the dentate gyrus (DG) and MF. To test whether this plastic change could be induced in a...

MANSOUR, A., R. DOYLE, R. KATZ AND E. S. VALENSTEIN. Long-lasting changes in morphine sensitivity following amygdaloid kindling in mice. PHYSIOL. BEHAV. 27(6) 1117-1120, 1981.--Mice tested at either 3, 27 or 90 days following their last amygdala kindled convulsion exhibited a marked increase in response to morphine compared to controls. Kindled animals showed a higher incidence of clonic convul...

10-20% of symptomatic epilepsies are post-traumatic. We examined effect of LPS preconditioning on epileptogenesis after controlled cortical impact (CCI). LPS (0.01, 0.1 and 0.5 mg/kg) was injected i.p. to rats 5 days before induction of CCI to parieto-temporal cortex. Kindling started 24h after CCI by i.p. injection of 30 mg/kg of pentylenetetrazole every other day until manifestation of 3 cons...

Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Methods: ...

Epilepsy is one of the common disorders in human community. Clinical observations have shown that epileptic patients have often difficulty in learning and memory. Kindling is a laboratory model for studying epilepsy and its complications. This experiment was designed to study the effect of chemical kindling on Schaffer collateral-CA1 pyramidal cell synaptic transmission using pentylenetetrazole...