نتایج جستجو برای: raphe nucleus

تعداد نتایج: 113232  

2016
Fanny Joubert Camille Loiseau Anne-Sophie Perrin-Terrin Florence Cayetanot Alain Frugière Nicolas Voituron Laurence Bodineau

We mapped and characterized changes in the activity of brainstem cell groups under hypoxia in one-day-old newborn mice, an animal model in which the central nervous system at birth is particularly immature. The classical biphasic respiratory response characterized by transient hyperventilation, followed by severe ventilation decline, was associated with increased c-FOS immunoreactivity in brain...

Journal: :Neuroendocrinology 2010
Karin V Weissheimer Skyla M Herod Judy L Cameron Cynthia L Bethea

BACKGROUND/AIMS We established a cynomolgus macaque model of stress-induced amenorrhea in which the application of combined metabolic and psychosocial stress suppressed ovulation in stress-sensitive (SS) individuals, but not in highly stress-resilient (HSR) individuals. We previously reported that SS monkeys have deficits in global serotonin release and serotonin-related gene expression in the ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Jonathan G McEuen Sheryl G Beck Tracy L Bale

Stress is a common trigger in affective disorder onset, yet the mechanism and predisposing factors of vulnerability remain unknown. Effective disease prevention requires a critical balance of responses within the serotonergic raphe nucleus, including a coordination of corticotropin-releasing factor (CRF) actions at both of its receptors, CRF receptor-1 and CRF receptor-2. Mice deficient in CRF ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997
T M Korman E Athan D W Spelman

We describe a patient with postsurgical anaerobic meningitis due to Peptostreptococcus magnus. In cases of meningitis associated with Peptostreptococcus species reported in the literature, the most common predisposing factors are meningorectal fistulae and head-and-neck surgery. Most patients respond well to appropriate antimicrobial therapy. Surgical intervention may be required in some instan...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1988
G K Wilcock M M Esiri D M Bowen A O Hughes

Cell counts have been performed on cholinergic subcortical nuclei, dorsal raphe nucleus, and locus caeruleus from up to 18 cases of Alzheimer's disease and 10 age-matched control subjects. In general, the extent of cell loss in these structures was similar. In the basal nucleus the anteromedial subdivision was the least, and the posterior subdivision the most affected. A subgroup of demented su...

Journal: :Journal of neurophysiology 1997
P Mason

Spinal serotonin is derived entirely from bulbar sources and plays an important role in spinal modulatory processes, including pain modulation. Establishing the electrophysiological properties of SEROTONERGIC bulbospinal neurons in the pontomedullary raphe and reticular formation is critical to understanding the physiological role of serotonin in the spinal cord. Neurons were characterized by t...

Journal: :The Journal of physiology 1996
G Woch R O Davies A I Pack L Kubin

1. The activity of most brainstem serotonergic cells is suppressed during sleep, particularly the rapid eye movement (REM) phase. Thus, they may play a major role in state-dependent changes in CNS functioning. Our main goal was to search for medullary raphe cells having axonal branches in the region of the hypoglossal (XII) motor nucleus and assess their behaviour during the atonia produced by ...

2013
Renato Leonardo de Freitas Luana Iacovelo Bolognesi André Twardowschy Fernando Morgan Aguiar Corrêa Nicola R Sibson Norberto Cysne Coimbra

Several studies have suggested the involvement of the hippocampus in the elaboration of epilepsy. There is evidence that suggests the hippocampus plays an important role in the affective and motivational components of nociceptive perception. However, the exact nature of this involvement remains unclear. Therefore, the aim of this study was to determine the role of muscarinic and nicotinic choli...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Rui Tao Sidney B Auerbach

Opioid receptor subtypes may have site-specific effects and play different roles in modulating serotonergic neurotransmission in the mammalian central nervous system. To test this hypothesis, we used in vivo microdialysis to measure changes in extracellular serotonin (5-hydroxytryptamine; 5-HT) in response to local infusion of mu-, delta-, and kappa-opioid receptor ligands into the dorsal raphe...

Journal: :Molecular pharmacology 2000
H Morikawa O J Manzoni J C Crabbe J T Williams

Although 5-HT(1B) receptors are believed to be expressed on nerve terminals, their precise mode of action is not fully understood because of the lack of selective antagonists. The 5-HT(1B) receptor knockout mouse was used in the present investigation to assess the function of 5-HT(1B) receptors in the modulation of synaptic transmission in three areas of the central nervous system: the dorsal r...

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