BACKGROUND Trial investigators frequently exclude patients from trial analyses which may bias estimates of the effect of treatment. Combining these estimates in a meta-analysis could aggregate any such biases. METHODS To investigate how excluding patients from trials can affect the results of both trials and meta-analyses, we used 14 meta-analyses of individual patient data (IPD) that address...

results the search criteria yielded 16 manuscripts on percutaneous adhesiolysis assessing post-surgery syndrome. of these, only 4 randomized trials met inclusion criteria for methodological quality assessment, 3 of them were of high quality; and the fourth manuscript was of low quality. based on these 3 randomized controlled trials, 2 of them with one-day procedure and one with a 3-day procedur...

Abstract Background Transcutaneous tibial nerve stimulation (TTNS) and percutaneous (PTNS) are effective safe therapies for overactive bladder (OAB) syndrome in adults. However, few randomized sham-controlled trials have been conducted a pediatric population. To our knowledge, both never compared children. Aim The aim of the complete study is twofold: (1) to assess efficacy TTNS therapy on symp...

Deficiencies of Selenium (Se) is correlated with the risk and onset autoimmune thyroid disease (AITD). The aim this study was to determine association between Se supplementation AITD. Methods: Electronic data searches 4 databases were performed. We assessed included studies using PRISMA for protocol assurance. Five met our inclusion criteria analyzed. predictor covariate in present administrati...

Abstract Background Pioglitazone is a promising therapeutic method for nonalcoholic fatty liver disease (NAFLD) patients with or without type 2 diabetes. However, there remarkable variability in treatment response. We analyzed our previous randomized controlled trial to examine the effects of gender and other factors on efficacy pioglitazone treating Chinese abnormal glucose metabolism. Methods...

BACKGROUND Cardiovascular disease (CVD) accounts for 30% of UK deaths. It is associated with modifiable lifestyle factors, including insufficient consumption of fruit and vegetables (F&V). Lay health trainers (LHTs) offer practical support to help people develop healthier behaviour and lifestyles. Our two-group pilot randomized controlled trial (RCT) investigated the effectiveness of LHTs at pr...

BACKGROUND Patients, now generally well informed through dedicated websites and support organizations, are beginning to look askance at clinical experimentation. We conducted a survey investigation to verify whether women with endometriosis would still accept to participate in a randomized controlled trial (RCT) on treatment for pelvic pain. METHODS A total of 500 patients consecutively self-...

Objective: To evaluate the effectiveness of intralesional bleomycin in comparison to cryotherapy treatment cutaneous warts. Method: The randomized controlled trial was conducted at Department Dermatology, Jinnah Postgraduate Medical Centre, Karachi, from January July 2021, and comprised patients either gender aged 18-60 years who had warts for 1-48 weeks. subjects were divided into group A trea...