Background Intravenous acetaminophen reaches a higher mean peak plasma concentration than oral in shorter period of time. The favorable pharmacokinetics intravenous may be beneficial for treating intrapartum maternal fever. Objective primary objective was to compare and time defervescence (temperature <38°C). secondary the percentage participants being afebrile percent reduction temperature 30 ...

OBJECTIVE Infantile colic is a painful condition in the first months of infancy. Acupuncture is used in Scandinavia as a treatment for infantile colic. A randomized controlled trial was carried out with the aim of testing the hypothesis that acupuncture treatment has a clinically relevant effect for this condition. DESIGN A prospective, blinding-validated, randomized controlled multicentre tr...

BACKGROUND Effective web-assisted tobacco interventions (WATIs) have been underutilized by smokers; moreover, despite practice guideline recommendations, clinical teams do not routinely refer smokers to WATIs. Our goal was to test a clinical practice innovation, an ePortal designed to change practice and patient behavior. Our hypotheses were that the integrated system would result in increased ...

The Action to Control Cardiovascular Disease in Diabetes (ACCORD) blood pressure trial is an unmasked, open-label, randomized trial with a sample size of 4,733 participants. This report describes the rationale, design, and methods of the blood pressure interventions in ACCORD. Participants eligible for the blood pressure trial are randomized to 1 of 2 groups with different treatment goals: syst...

BACKGROUND Self-control is an important ability in everyday life, showing associations with health-related outcomes. The aim of the Self-control and Mindfulness within Ambulatorily assessed network Systems across Health-related domains (SMASH) study is twofold: first, the effectiveness of a computer-based mindfulness training will be evaluated in a randomized controlled trial. Second, the SMASH...

The trial discussed here investigates amoxicillin treatment of non-severe pneumonia in children; it also looks at relapse. Respiratory infections kill two million children annually [2]. This is a randomized control trial with intention to treat basis [3],[4],[5]. The primary outcome of this trial is treatment failure; the rate of relapse was a secondary outcome. The CASP tool was used to apprai...