evidence based medicine is very important for success of modern medicine. it is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. it not only identifi...

Singer et al. recently published the results of long-awaited TICACOS-International randomized controlled trial (RCT), which found no benefit indirect calorimetry (IC)-guided feeding in mixed intensive care unit (ICU) patients, as compared to up a calculated energy target [ [1] P. De Waele E. Sanchez C. Ruiz Santana S. Montejo J.C. Laterre P.F. TICACOS international: multi-center, randomized, pr...

Abstract We have been asked to consider the feasibility of piloting a Citizens’ Basic Income (CBI): basic, unconditional, universal, individual, regular payment that would replace aspects social security and be introduced alongside changes taxes. Piloting evaluating CBI as Cluster Randomized Control Trial (RCT) raises question whether intervention comparison groups in equipoise, thus randomizat...

Significance: Diabetic foot ulcers (DFU) significantly add to global economic, social, and clinical burdens. Healing a DFU fast and well limits complications that can lead to lower extremity amputation, morbidity, and mortality. Recent Advances: Many promising topical DFU healing agents have been studied in randomized clinical trials (RCT), but only one, becaplermin, has been cleared for this u...

introduction: performing correct research in different aspects of community as well as medical sciences can be a way to resolve many problems. in order to create a systematic knowledge of research method in academic members of arak university of medical sciences and enabling them in providing proposals and performing researches, a clinical research center was developed. this study is done to in...

The rise of biomedicine is usually associated with the transformation of biological and medical research in the United States following the vast expansion of funding, both private and public, in the years after the Second World War. Along with the other authors in this issue, we are interested in describing this phenomenon in national contexts other than the United States. Our discussion of bio...

leagues in the June 2004 Canadian Journal of Surgery (volume 47, pages 200–208) nicely takes readers through the process of assessing the value of a randomized clinical trial (RCT) in surgery. These steps are based on the invaluable work of the Evidence-Based Medicine Working Group (EBMWG). Considerable effort has also gone into standardizing reportage of RCTs. Thoma’s article has 35 references...

BACKGROUND Recent trials have shown improved depression outcomes with chronic care models. We report the methods of a project that assesses the sustainability and transportability of a chronic care model for depression and change strategy. METHODS In a randomized controlled trial (RCT), a clinical model for depression was implemented through a strategy supporting practice change. The clinical...

OBJECTIVES High-quality clinical evidence is most often lacking when novel high-risk devices enter the European market. At the same time, a randomized controlled trial (RCT) is often initiated as a requirement for obtaining market access in the US. Should coverage in Europe be postponed until RCT data are available? We studied the premarket clinical evaluation of innovative high-risk medical de...

Endovascular coiling has become the primary treatment modality for the treatment of intracranial ruptured aneurysms in many centers. A multicenter randomized controlled trial (RCT), ISAT study, has demonstrated that endovascular coiling of ruptured intracranial aneurysms has benefits over surgical clipping in those patients suitable for either treatment. Because RCT comparing conservative manag...