Several studies demonstrate an association between osteoporosis and arterial calcific disease, both of which being common in elderly women. Estradiol and raloxifene, a selective estrogen receptor modulator, prevent bone loss in postmenopausal women. Little is known regarding how these agents affect arterial calcification. The aim of this study was to determine whether or not 17beta-estradiol an...

Release of high levels of nitric oxide (NO) is associated with osteoblastic cell death. The mechanisms of NO-induced cytotoxicity are not well documented and it is presently not known if estrogenic compounds prevent this effect. We studied the role of ceramides in cell death induced by the NO donor sodium nitroprusside (SNP) and we tested the possibility that 17beta-estradiol, the anti-estrogen...

phene that binds ta estrogen receptars and inhibits bone resorption without stimulating the uterine endametrium in pastmenapausal women.1 However, the effect of raloxifene on the risk of fracture is not knawn. Observational studies in postmenapausaI women have suggested that langterm estragen therapy reduces the inciContext Raloxifene hydrochloride, a selective estrogen receptor modulator, prev...

In recent years, the potential of marine natural products as anticancer agents, specifically for breast cancer, has been examined. The sea cucumber (Holothuroidea: Echinodermata) is known to contain triterpene glycosides, which have shown anticancer or cytotoxic activity. In this research, molecular docking of selected sea cucumber bioactive compounds was conducted on five receptor targets that...

background: the effects of estrogene on central nervous system are still controversial. objective: we aimed to investigate the effects of raloxifene on the antioxidant enzyme [superoxide dismutase (sod) and catalase (cat)] activities and malondialdehyde (mda) levels in brain homogenates of ovariectomized female rats and its effect on cognitive process of learning. materials and methods: female ...

The recognition of a new group of drugs, now named selective estrogen receptor modulators (SERMs) has revolutionized prospects for the prevention of breast cancer. New agents will continue to be tested against tamoxifen, the first SERM and an established treatment of ER positive breast cancer. Raloxifene a related SERM is used to treat and prevent osteoporosis with the potential beneficial side...

Over the last 5 years, the results of several breast cancer prevention trials have demonstrated the usefulness of antiestrogen selective estrogen receptor modulators (SERMs) for the prevention of breast cancer. The National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 breast cancer prevention trial was the first trial to show a major benefit of a SERM: The anti-estrogen SERM tamoxifen...

A sensitive determination procedure was presented for two anticancer drugs (tamoxifen and raloxifene) in real water biological samples based on magnetic dispersive micro solid-phase extraction–high-performance liquid chromatography with an ultraviolet detector. Fe3O4 NPs@SiO2@TiO2 nanocomposite synthesised as a sorbent by the sol-gel technique. The effective parameters were optimised experiment...