Radium has been described (I have forgotten by whom,) as the most potent element which has been yet discovered for the production of discontent in the medical profession. It was hailed at first as a panacea for all ills. Although it has not fulfilled the hopes based upon it by those early enthusiasts, it has opened up new fields in the treatment of disease, especially malignant disease, but eve...

I t is well known that radium rays, as well as x-rays, are capable of affecting the living cell. Bergoni~ and Tribondeau 1 from extensive experimental studies made the generalization 2,3 that: "Immature cells and cells in an active state of division are more sensitive to the x-rays than are cells which have already acquired their fixed adult, morphological or physiological characters. ''2 Subse...

Background and Purpose. Radium-223 dichloride (Xofigo®, Bayer HealthCare Pharmaceuticals Inc.) is the first α-particle emitter therapeutic agent approved by the FDA, with benefits in overall survival and delay in symptomatic skeletal event for patients with metastatic castrate-resistant prostate cancer (CRPC). Recent post hoc analyses of the phase III ALSYMPCA trial support the previously estab...

Improving options for patients with metastatic castration-resistant prostate cancer (mCRPC) provide latitude in designing treatment plans that meet patients' medical needs and personal goals. The field's rapid evolution opens avenues for contributions by multiple medical specialties and requires considering more options to ensure that each patient receives the most appropriate care. A multidisc...