A 13-year-old girl with a right intraorbital optic nerve glioma (ONG) was referred to our glaucoma clinic because of uncontrolled intraocular pressure (IOP) in her right eye. The IOP reached as high as 80 mmHg. Several months earlier, she had undergone stereotactic image-guided robotic radiosurgery using the CyberKnife for her ONG; the mass had become smaller after treatment. Her visual acuity ...

Stereotactic radiosurgery (SRS) provides excellent control in the treatment of brain metastases (BM). The use of newer, targeted and immunotherapy treatments have resulted in improved overall survival in patients even with an extensive metastatic disease. Hence, it is increasingly important to consider the potential for late toxicities like radiation-induced necrosis (RN) of the brain. We prese...

In radiosurgery, a moving beam of radiation acts as an ablative surgical instrument. Conventional systems for radiosurgery use a cylindrical radiation beam of xed cross-section. The radiation source can only be moved along simple standardized paths. A new radiosurgical system based on a six degree-of-freedom robotic arm has been developed to overcome limitations of conventional systems. We addr...

In radiosurgery, a moving beam of radiation acts as an ablative surgical instrument. Conventional systems for radiosurgery use a cylindrical radiation beam of fixed cross section. The radiation source can be moved only along simple, standardized paths. A new radiosurgical system based on a six-degree-of-freedom robotic arm has been developed to overcome limitations of conventional systems. We a...

The linear-quadratic (LQ) model is widely used to model the effect of total dose and dose per fraction in conventionally fractionated radiotherapy. Much of the data used to generate the model are obtained in vitro at doses well below those used in radiosurgery. Clinically, the LQ model often underestimates tumor control observed at radiosurgical doses. The underlying mechanisms implied by the L...

Acromegaly is debilitating disease occasionally refractory to surgical and medical treatment. Stereotactic radiosurgery, and in particular Gamma Knife surgery (GKS), has proven to be an effective noninvasive adjunct to traditional treatments, leading to disease remission in a substantial proportion of patients. Such remission holds the promise of eliminating the need for expensive medications, ...

In radiosurgery, a moving beam of radiation acts as an ablative surgical instrument. Conventional systems for radiosurgery use a cylindrical radiation beam of xed cross-section. The radiation source can only be moved along simple standardized paths. A new radiosurgical system based on a six degree-of-freedom robotic arm has been developed to overcome limitations of conventional systems. We addr...

The aim of conformal radiation therapy and of radiosurgery (Gamma Knife and Multi-beam radiosurgery) is to irradiate the pathological target volume with ionising radiation while avoiding as well as possible the surrounding normal tissues. Considering the accuracy of these treatments, it is interesting to compare the different techniques to evaluate their effectiveness. This comparison involves ...

Standard treatment of cerebral alveolar hydatid disease consists of open brain surgery and systemic albendazole. We describe a patient with inoperable cerebral alveolar hydatid cysts on whom gamma knife radiosurgery was used instead of open brain surgery. Because of the size of the multicystic lesion, the gamma knife procedure was done in two sessions. Repeated courses of albendazole were given...

The goal of this work was to further improve an experimental proton radiosurgery system at Loma Linda University Medical Center to reach sub-millimeter accuracy before proton radiosurgery with narrow beams can be used in a clinical trial. Radiosurgery precisely targets a specific anatomical region with high doses of radiation. We have developed a program that provides correcting translational o...